Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
panDAspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (115 aa)    
Predicted Functional Partners:
panC
Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.
 
 
 0.995
panB
3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.
  
  
 0.917
coaX
Putative transcriptional acitvator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
 
  
 0.855
purA
Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
    
 0.831
Tlet_0297
PFAM: aminotransferase class I and II; KEGG: tma:TM1255 aspartate aminotransferase.
    
 0.830
Tlet_0495
PFAM: aminotransferase class I and II; KEGG: tma:TM1698 aspartate aminotransferase.
    
 0.830
Tlet_1027
PFAM: fumarate lyase; KEGG: tma:TM0444 aspartate ammonia-lyase.
     
 0.826
Tlet_0136
TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate transcarbamylase regulatory subunit; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; KEGG: tma:TM1642 aspartate carbamoyltransferase, catalytic and regulatory chains.
    
  0.804
argG
PFAM: argininosuccinate synthase; KEGG: tma:TM1780 argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily.
     
  0.800
Tlet_0908
TIGRFAM: aspartate racemase; PFAM: Asp/Glu racemase; KEGG: bca:BCE_0308 aspartate racemase.
     
  0.800
Your Current Organism:
Pseudothermotoga lettingae
NCBI taxonomy Id: 416591
Other names: P. lettingae TMO, Pseudothermotoga lettingae TMO, Pseudothermotoga lettingae str. TMO, Pseudothermotoga lettingae strain TMO, Thermotoga lettingae TMO, Thermotoga sp. TMO
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