Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Tlet_0899PFAM: cobalamin B12-binding domain protein; KEGG: tte:TTE0924 methionine synthase I, cobalamin-binding domain. (544 aa)    
Predicted Functional Partners:
Tlet_0900
PFAM: UDP-glucose/GDP-mannose dehydrogenase; NAD/NADP octopine/nopaline dehydrogenase; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; Ketopantoate reductase ApbA/PanE domain protein; KEGG: tte:TTE0923 NAD/NADP octopine/nopaline dehydrogenas.
 
     0.949
Tlet_0898
D-alanine--D-alanine ligase; PFAM: phosphoribosylglycinamide synthetase; protein of unknown function DUF201; D-alanine--D-alanine ligase domain protein; KEGG: ade:Adeh_2449 D-alanine--D-alanine ligase.
 
     0.811
rnhB
Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.
       0.773
Tlet_0183
Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
   
   0.608
deoC
Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
   
   0.608
Tlet_1712
PFAM: D-Lysine 56-aminomutase alpha subunit; KEGG: tte:TTE0726 D-lysine 5,6-aminomutase alpha subunit.
   
   0.608
Tlet_0896
TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; KEGG: tma:TM0943 glutamine synthetase.
       0.541
Tlet_0901
PFAM: NUDIX hydrolase; KEGG: bmb:BruAb1_1543 MutT/nudix family protein.
       0.496
Tlet_0902
TIGRFAM: dihydropteroate synthase; PFAM: dihydropteroate synthase DHPS; KEGG: tma:TM0040 dihydropteroate synthase.
       0.496
Tlet_0892
PFAM: cation transporter; KEGG: tma:TM1089 TRK system potassium uptake protein TrkH.
       0.471
Your Current Organism:
Pseudothermotoga lettingae
NCBI taxonomy Id: 416591
Other names: P. lettingae TMO, Pseudothermotoga lettingae TMO, Pseudothermotoga lettingae str. TMO, Pseudothermotoga lettingae strain TMO, Thermotoga lettingae TMO, Thermotoga sp. TMO
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