STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tlet_0963PFAM: Phosphoglycerate mutase; KEGG: tma:TM1374 phosphoglycerate mutase. (197 aa)    
Predicted Functional Partners:
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
    
 0.924
Tlet_1767
PFAM: aminotransferase class V; KEGG: tma:TM1400 putative aminotransferase.
  
 
 0.921
Tlet_1811
PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: ava:Ava_2749 pyridoxal-5'-phosphate-dependent enzyme, beta subunit.
 
  
  0.917
Tlet_1944
TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, alpha subunit; PFAM: serine dehydratase alpha chain; KEGG: mta:Moth_1946 L-serine dehydratase, iron-sulfur-dependent, alpha subunit.
  
 
  0.907
Tlet_1945
TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, beta subunit; PFAM: serine dehydratase beta chain; KEGG: chy:CHY_2458 L-serine dehydratase, iron-sulfur-dependent, beta subunit.
  
 
  0.907
trpB
Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
     
  0.900
Tlet_0974
TIGRFAM: serine O-acetyltransferase; KEGG: tma:TM0666 serine acetyltransferase.
     
 0.810
Tlet_0964
PFAM: OsmC family protein; KEGG: tma:TM0919 putative redox protein.
  
    0.680
Tlet_0965
PFAM: Appr-1-p processing domain protein; KEGG: tma:TM0508 putative ATPase.
  
  
 0.673
cobS
Cobalamin-5-phosphate synthase CobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.
 
  
 0.614
Your Current Organism:
Pseudothermotoga lettingae
NCBI taxonomy Id: 416591
Other names: P. lettingae TMO, Pseudothermotoga lettingae TMO, Pseudothermotoga lettingae str. TMO, Pseudothermotoga lettingae strain TMO, Thermotoga lettingae TMO, Thermotoga sp. TMO
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