STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tlet_0987PAS/PAC sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-4 domain protein; KEGG: tma:TM1654 sensor histidine kinase HpkA. (421 aa)    
Predicted Functional Partners:
Tlet_0986
Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein; KEGG: tma:TM1655 response regulator DrrA.
 
 0.992
Tlet_1009
PFAM: response regulator receiver; KEGG: tma:TM0468 response regulator.
 
 0.982
Tlet_1013
Protein-glutamate O-methyltransferase; PFAM: MCP methyltransferase CheR-type; Methyltransferase type 11; KEGG: tma:TM0464 putative chemotaxis protein methyltransferase.
    
 0.920
Tlet_0389
PFAM: periplasmic binding protein/LacI transcriptional regulator; KEGG: dge:Dgeo_2825 periplasmic binding protein/LacI transcriptional regulator.
 
 
  
 0.901
Tlet_0990
TIGRFAM: translation elongation factor G; small GTP-binding protein; PFAM: elongation factor G domain protein; protein synthesis factor GTP-binding; elongation factor Tu domain 2 protein; elongation factor G domain IV; KEGG: tma:TM1651 elongation factor EF-G.
   
 
 0.894
Tlet_1703
Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein; KEGG: tma:TM1259 phosphate regulon transcriptional regulatory protein PhoB.
 
 0.894
Tlet_0961
Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein; KEGG: bce:BC0572 two-component response regulator.
 
 0.892
Tlet_1002
Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein; KEGG: rxy:Rxyl_3017 two component transcriptional regulator, winged helix family.
 
 0.874
Tlet_0988
TIGRFAM: pyrimidine-nucleoside phosphorylase; PFAM: glycosyl transferase family 3; Pyrimidine nucleoside phosphorylase domain; KEGG: tma:TM1653 pyrimidine-nucleoside phosphorylase.
  
  
 0.838
Tlet_0989
KEGG: tma:TM1652 hypothetical protein.
  
    0.835
Your Current Organism:
Pseudothermotoga lettingae
NCBI taxonomy Id: 416591
Other names: P. lettingae TMO, Pseudothermotoga lettingae TMO, Pseudothermotoga lettingae str. TMO, Pseudothermotoga lettingae strain TMO, Thermotoga lettingae TMO, Thermotoga sp. TMO
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.