STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tlet_1365PFAM: dihydropteroate synthase DHPS; homocysteine S-methyltransferase; Methionine synthase B12-binding module cap domain protein; cobalamin B12-binding domain protein; KEGG: tma:TM0268 5-methyltetrahydrofolate S-homocysteine methyltransferase. (773 aa)    
Predicted Functional Partners:
Tlet_1361
PFAM: methylenetetrahydrofolate reductase; KEGG: gfo:orf331 methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.
 
 
 0.999
Tlet_1363
Protein of unknown function DUF39; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; protein of unknown function DUF39; KEGG: mth:MTH855 inosine-5'-monophosphate dehydrogenase related protein VIII.
    
 0.992
Tlet_0460
Cystathionine gamma-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: tvo:TVN0174 cystathionine gamma-lyase.
 
 
 0.984
Tlet_0879
TIGRFAM: adenosylhomocysteinase; PFAM: S-adenosyl-L-homocysteine hydrolase; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: tma:TM0172 adenosylhomocysteinase.
  
 
 0.970
metK
Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
 
 0.969
fhs
PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: tma:TM1766 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family.
  
 
 0.968
Tlet_1366
KEGG: tma:TM0269 hypothetical protein.
 
  
 0.966
gcvT
Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine.
  
 
 0.964
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
   
 
 0.954
Tlet_1859
PFAM: aminotransferase class I and II; KEGG: cac:CAC2970 PLP-dependent aminotransferase.
     
 0.948
Your Current Organism:
Pseudothermotoga lettingae
NCBI taxonomy Id: 416591
Other names: P. lettingae TMO, Pseudothermotoga lettingae TMO, Pseudothermotoga lettingae str. TMO, Pseudothermotoga lettingae strain TMO, Thermotoga lettingae TMO, Thermotoga sp. TMO
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