STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tlet_1395TIGRFAM: uridine kinase; PFAM: phosphoribulokinase/uridine kinase; KEGG: sha:SH1308 uridine kinase. (204 aa)    
Predicted Functional Partners:
upp
Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate.
 
 0.995
pyrH
Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.
   
 
 0.924
Tlet_0870
PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: tma:TM1878 UDP-sugar hydrolase; Belongs to the 5'-nucleotidase family.
 
 
 0.924
Tlet_0713
PFAM: metallophosphoesterase; KEGG: hpy:HP0104 2',3'-cyclic-nucleotide 2'-phosphodiesterase (CpdB).
 
 
 0.922
cmk
TIGRFAM: cytidylate kinase; PFAM: cytidylate kinase region; KEGG: tma:TM1443 cytidylate kinase.
   
 
 0.922
Tlet_0988
TIGRFAM: pyrimidine-nucleoside phosphorylase; PFAM: glycosyl transferase family 3; Pyrimidine nucleoside phosphorylase domain; KEGG: tma:TM1653 pyrimidine-nucleoside phosphorylase.
    
 0.921
Tlet_1286
Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.
    
 0.921
Tlet_1922
Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
  
 0.917
Tlet_0516
PFAM: phosphoribulokinase/uridine kinase; KEGG: tma:TM0751 uridine kinase.
  
  
 
0.916
pyrR
Uracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
     
 0.915
Your Current Organism:
Pseudothermotoga lettingae
NCBI taxonomy Id: 416591
Other names: P. lettingae TMO, Pseudothermotoga lettingae TMO, Pseudothermotoga lettingae str. TMO, Pseudothermotoga lettingae strain TMO, Thermotoga lettingae TMO, Thermotoga sp. TMO
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