STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thiCThiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (424 aa)    
Predicted Functional Partners:
Tlet_1753
PFAM: Phosphomethylpyrimidine kinase type-1; KEGG: tma:TM0790 phosphomethylpyrimidine kinase.
 
 
 0.998
Tlet_1748
PFAM: Radical SAM domain protein; biotin and thiamin synthesis associated; KEGG: tma:TM1267 thiH protein, putative.
  
 0.947
thi4
Thiazole biosynthesis enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
  
  
 0.904
purM
TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein; KEGG: tte:TTE0590 Phosphoribosylaminoimidazol (AIR) synthetase.
    
 0.815
Tlet_0328
PFAM: UBA/THIF-type NAD/FAD binding protein; KEGG: smr:Smar_0789 UBA/ThiF-type NAD/FAD binding protein.
 
  
 0.814
Tlet_1594
Hypothetical protein.
  
  
 0.813
Tlet_1752
PFAM: Xylose isomerase domain protein TIM barrel; KEGG: tma:TM0789 hypothetical protein.
       0.812
Tlet_1754
PFAM: protein-L-isoaspartate(D-aspartate) O-methyltransferase; KEGG: tma:TM0704 L-isoaspartate(D-aspartate) O-methyltransferase.
       0.707
Tlet_1755
PFAM: alpha-2-macroglobulin; alpha-2-macroglobulin domain protein; KEGG: tma:TM0984 hypothetical protein.
       0.668
Tlet_1756
KEGG: tma:TM0985 hypothetical protein.
       0.668
Your Current Organism:
Pseudothermotoga lettingae
NCBI taxonomy Id: 416591
Other names: P. lettingae TMO, Pseudothermotoga lettingae TMO, Pseudothermotoga lettingae str. TMO, Pseudothermotoga lettingae strain TMO, Thermotoga lettingae TMO, Thermotoga sp. TMO
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