node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
guaA | guaB | llmg_1008 | llmg_0230 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Inositol-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
guaA | guaC | llmg_1008 | llmg_1412 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.999 |
guaA | hprT | llmg_1008 | llmg_0993 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | HprT protein; PF00156.12: Phosphoribosyltransferase; High confidence in function and specificity; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.946 |
guaA | hpt | llmg_1008 | llmg_0020 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | [EC:2.4.2.8], Hypoxanthine phosphoribosyltransferase (EC 2.4.2.8) (HPRT)., Hypoxanthine phosphoribosyl transferase, Phosphoribosyl transferase domain, HGPRTase: hypoxanthine phosphoribosyltransferase; High confidence in function and specificity; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.964 |
guaA | llmg_0192 | llmg_1008 | llmg_0192 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 5'-nucleotidase precursor, Phosphoesterase-related protein; High confidence in function and specificity; Belongs to the 5'-nucleotidase family. | 0.918 |
guaA | llmg_1188 | llmg_1008 | llmg_1188 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.959 |
guaA | nucA | llmg_1008 | llmg_1479 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 5'-nucleotidase; High confidence in function and specificity. | 0.900 |
guaA | purA | llmg_1008 | llmg_2201 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Putative adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.949 |
guaA | purH | llmg_1008 | llmg_0994 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase; High confidence in function and specificity. | 0.819 |
guaA | xpt | llmg_1008 | llmg_1346 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.991 |
guaB | guaA | llmg_0230 | llmg_1008 | Inositol-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.999 |
guaB | guaC | llmg_0230 | llmg_1412 | Inositol-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.927 |
guaB | hprT | llmg_0230 | llmg_0993 | Inositol-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | HprT protein; PF00156.12: Phosphoribosyltransferase; High confidence in function and specificity; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.907 |
guaB | hpt | llmg_0230 | llmg_0020 | Inositol-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | [EC:2.4.2.8], Hypoxanthine phosphoribosyltransferase (EC 2.4.2.8) (HPRT)., Hypoxanthine phosphoribosyl transferase, Phosphoribosyl transferase domain, HGPRTase: hypoxanthine phosphoribosyltransferase; High confidence in function and specificity; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.907 |
guaB | llmg_0192 | llmg_0230 | llmg_0192 | Inositol-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 5'-nucleotidase precursor, Phosphoesterase-related protein; High confidence in function and specificity; Belongs to the 5'-nucleotidase family. | 0.904 |
guaB | llmg_1188 | llmg_0230 | llmg_1188 | Inositol-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.923 |
guaB | nucA | llmg_0230 | llmg_1479 | Inositol-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 5'-nucleotidase; High confidence in function and specificity. | 0.900 |
guaB | purA | llmg_0230 | llmg_2201 | Inositol-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Putative adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.991 |
guaB | purH | llmg_0230 | llmg_0994 | Inositol-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase; High confidence in function and specificity. | 0.959 |
guaB | xpt | llmg_0230 | llmg_1346 | Inositol-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.960 |