kinC protein (Lactococcus lactis) - STRING interaction network

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

kinC

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, cztS_silS_copS: heavy metal sensor kinase; High confidence in function and specificity. (475 aa)

Predicted Functional Partners:

llrC

0.999

llrB

0.919

llrA

0.915

llrE

0.896

llrF

0.865

llrG

0.819

rbsB

0.801

vicX

0.678

tmk

0.563

rcfB

0.531

Your Current Organism:

Lactococcus lactis

NCBI taxonomy Id: 416870
Other names: L. lactis subsp. cremoris MG1363, Lactococcus lactis subsp. cremoris MG1363, Lactococcus lactis subsp. cremoris str. MG1363, Lactococcus lactis subsp. cremoris strain MG1363

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
kinC	llrA	llmg_0413	llmg_0908	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, cztS_silS_copS: heavy metal sensor kinase; High confidence in function and specificity.	Two-component system regulator llrA; Contains response regulator receiver domain; High confidence in function and specificity.	0.915
kinC	llrB	llmg_0413	llmg_1068	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, cztS_silS_copS: heavy metal sensor kinase; High confidence in function and specificity.	Two-component system regulator llrB; Response regulator receiver domain; High confidence in function and specificity.	0.919
kinC	llrC	llmg_0413	llmg_0414	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, cztS_silS_copS: heavy metal sensor kinase; High confidence in function and specificity.	Two-component system regulator; Response regulator receiver domain, PhoB: Phosphate regulon transcriptional regulatory protein phoB; Conserved hypothetical protein.	0.999
kinC	llrE	llmg_0413	llmg_1520	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, cztS_silS_copS: heavy metal sensor kinase; High confidence in function and specificity.	Two-component system regulator llrE; Response regulator receiver domain; High confidence in function and specificity.	0.896
kinC	llrF	llmg_0413	llmg_0747	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, cztS_silS_copS: heavy metal sensor kinase; High confidence in function and specificity.	Two-component system regulator llrF; Response regulator receiver domain; High confidence in function and specificity.	0.865
kinC	llrG	llmg_0413	llmg_1929	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, cztS_silS_copS: heavy metal sensor kinase; High confidence in function and specificity.	Response regulator; Conserved hypothetical protein.	0.819
kinC	rbsB	llmg_0413	llmg_0789	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, cztS_silS_copS: heavy metal sensor kinase; High confidence in function and specificity.	Ribose ABC transporter substrate binding protein RbsB; High confidence in function and specificity.	0.801
kinC	rcfB	llmg_0413	llmg_2512	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, cztS_silS_copS: heavy metal sensor kinase; High confidence in function and specificity.	Transcriptional regulator; IPR000595: cNMP_binding, CRP/FNR family of transcription regulators; Family membership.	0.531
kinC	tmk	llmg_0413	llmg_0415	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, cztS_silS_copS: heavy metal sensor kinase; High confidence in function and specificity.	Tmk protein; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.	0.563
kinC	vicX	llmg_0413	llmg_0412	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, cztS_silS_copS: heavy metal sensor kinase; High confidence in function and specificity.	Ribonuclease Z (tRNA 3 endonuclease)., Beta-lactamase-like, Metallo-beta-lactamase superfamily; High confidence in function and specificity.	0.678
llrA	kinC	llmg_0908	llmg_0413	Two-component system regulator llrA; Contains response regulator receiver domain; High confidence in function and specificity.	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, cztS_silS_copS: heavy metal sensor kinase; High confidence in function and specificity.	0.915
llrA	rcfB	llmg_0908	llmg_2512	Two-component system regulator llrA; Contains response regulator receiver domain; High confidence in function and specificity.	Transcriptional regulator; IPR000595: cNMP_binding, CRP/FNR family of transcription regulators; Family membership.	0.763
llrB	kinC	llmg_1068	llmg_0413	Two-component system regulator llrB; Response regulator receiver domain; High confidence in function and specificity.	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, cztS_silS_copS: heavy metal sensor kinase; High confidence in function and specificity.	0.919
llrC	kinC	llmg_0414	llmg_0413	Two-component system regulator; Response regulator receiver domain, PhoB: Phosphate regulon transcriptional regulatory protein phoB; Conserved hypothetical protein.	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, cztS_silS_copS: heavy metal sensor kinase; High confidence in function and specificity.	0.999
llrC	rcfB	llmg_0414	llmg_2512	Two-component system regulator; Response regulator receiver domain, PhoB: Phosphate regulon transcriptional regulatory protein phoB; Conserved hypothetical protein.	Transcriptional regulator; IPR000595: cNMP_binding, CRP/FNR family of transcription regulators; Family membership.	0.753
llrC	tmk	llmg_0414	llmg_0415	Two-component system regulator; Response regulator receiver domain, PhoB: Phosphate regulon transcriptional regulatory protein phoB; Conserved hypothetical protein.	Tmk protein; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.	0.521
llrC	vicX	llmg_0414	llmg_0412	Two-component system regulator; Response regulator receiver domain, PhoB: Phosphate regulon transcriptional regulatory protein phoB; Conserved hypothetical protein.	Ribonuclease Z (tRNA 3 endonuclease)., Beta-lactamase-like, Metallo-beta-lactamase superfamily; High confidence in function and specificity.	0.753
llrE	kinC	llmg_1520	llmg_0413	Two-component system regulator llrE; Response regulator receiver domain; High confidence in function and specificity.	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, cztS_silS_copS: heavy metal sensor kinase; High confidence in function and specificity.	0.896
llrF	kinC	llmg_0747	llmg_0413	Two-component system regulator llrF; Response regulator receiver domain; High confidence in function and specificity.	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, cztS_silS_copS: heavy metal sensor kinase; High confidence in function and specificity.	0.865
llrG	kinC	llmg_1929	llmg_0413	Response regulator; Conserved hypothetical protein.	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, cztS_silS_copS: heavy metal sensor kinase; High confidence in function and specificity.	0.819

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Network Stats

number of nodes:

11

number of edges:

25

average node degree:

4.55

avg. local clustering coefficient:

0.858

expected number of edges:

11

PPI enrichment p-value:

0.000149

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016051

Carbohydrate biosynthetic process

4 of 19

1.48

1.04

0.0045

GO:0005975

Carbohydrate metabolic process

7 of 86

1.06

0.96

0.00046

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000287

Magnesium ion binding

4 of 34

1.22

0.63

0.0353

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:981

Carbon metabolism, and Streptomycin biosynthesis

6 of 31

1.44

1.7

1.61e-05

CL:1910

Polysaccharide biosynthetic process, and Glycosyl transferases group 1

3 of 6

1.85

1.44

0.0012

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

clo00521

Streptomycin biosynthesis

4 of 7

1.91

2.13

3.01e-05

clo00010

Glycolysis / Gluconeogenesis

4 of 19

1.48

1.39

0.00039

clo00030

Pentose phosphate pathway

3 of 14

1.48

1.11

0.0030

clo00500

Starch and sucrose metabolism

3 of 16

1.43

1.06

0.0034

clo00520

Amino sugar and nucleotide sugar metabolism

3 of 17

1.4

1.04

0.0034

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0413

Isomerase

4 of 34

1.22

0.77

0.0129

KW-0312

Gluconeogenesis

2 of 5

1.76

0.74

0.0363

KW-0328

Glycosyltransferase

3 of 21

1.31

0.65

0.0363

KW-0808

Transferase

6 of 178

0.68

0.41

0.0363

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