STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
llmg_0769Putative DivIVA cell division initiation protein; Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation. (128 aa)    
Predicted Functional Partners:
pbp2A
Penicillin-binding protein 2a; PF00912: Transglycosylase; High confidence in function and specificity.
   
 
 0.794
ezrA
Septation ring formation regulator; Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization; Belongs to the EzrA family.
  
 
 0.793
ftsQ
Cell division protein ftsQ; Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex; Belongs to the FtsQ/DivIB family. DivIB subfamily.
 
   
 0.772
ponA
Putative penicillin-binding protein 1a; Includes: Penicillin- insensitive transglycosylase (EC 2.4.2.-) (Peptidoglycan TGase); Penicillin-sensitive transpeptidase (EC 3.4.-.-) (DD-transpeptidase)]., PBP_1a_fam: penicillin-binding protein, 1A family; High confidence in function and specificity.
 
 
 
 0.680
holA
Putative DNA polymerase III, delta subunit; High confidence in function and specificity.
 
     0.679
llmg_0515
Conserved hypothetical protein; Uncharacterised protein family (UPF0223); Belongs to the UPF0223 family.
  
     0.676
ftsK
DNA translocase ftsK; Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the difSL recombination site, which is located within the replication terminus region (By similarity). Required for activation of the XerS recombinase, allowing activation of chromosome unlinking by recombination; Belongs to the FtsK/SpoIIIE/SftA family.
     
 0.649
pbp2B
Penicillin-binding protein 2B; High confidence in function and specificity.
 
  
 0.637
pbp1B
Penicillin-binding protein 1B; High confidence in function and specificity.
 
 
 
 0.628
mreC
Cell shape determining protein mreC; Involved in formation and maintenance of cell shape.
  
 
 0.609
Your Current Organism:
Lactococcus lactis
NCBI taxonomy Id: 416870
Other names: L. lactis subsp. cremoris MG1363, Lactococcus lactis subsp. cremoris MG1363, Lactococcus lactis subsp. cremoris str. MG1363, Lactococcus lactis subsp. cremoris strain MG1363
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.