STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gltBGlutamate synthase, large subunit; PF01645: Conserved region in glutamate synthase; High confidence in function and specificity. (1489 aa)    
Predicted Functional Partners:
gltD
TIGR01317: glutamate synthases, NADH/NADPH, small subunit; High confidence in function and specificity.
 0.999
glnA
GlnA protein; PF00120: Glutamine synthetase, catalytic domain, TIGR00653: glutamine synthetase, type I; High confidence in function and specificity.
  
 
 0.987
gltA
GltA protein; cit_synth_II: 2-methylcitrate synthase/citrate synthase II; High confidence in function and specificity; Belongs to the citrate synthase family.
    
 0.985
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
  
 0.972
carB
Carbamoyl-phosphate synthase, large subunit; Region start changed from 1046934 to 1046961 (-27 bases); Belongs to the CarB family.
  
 
 0.971
gadB
Glutamate decarboxylase; Converts internalized glutamate to GABA and increases the internal pH. Involved in glutamate-dependent acid resistance; Belongs to the group II decarboxylase family.
    
 0.961
icd
Isocitrate dehydrogenase; High confidence in function and specificity.
  
 
 0.959
glmS
Glucosamine-fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
   
 0.956
purF
Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
    
 0.945
carA
Carbamoyl-phosphate synthase small chain; High confidence in function and specificity; Belongs to the CarA family.
    
  0.924
Your Current Organism:
Lactococcus lactis
NCBI taxonomy Id: 416870
Other names: L. lactis subsp. cremoris MG1363, Lactococcus lactis subsp. cremoris MG1363, Lactococcus lactis subsp. cremoris str. MG1363, Lactococcus lactis subsp. cremoris strain MG1363
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