STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hisBHisB protein; PF00475: Imidazoleglycerol-phosphate dehydratase; High confidence in function and specificity. (199 aa)    
Predicted Functional Partners:
hisI
EC:3.6.1.31, PF01503: Phosphoribosyl-ATP pyrophosphohydrolase, PF01502: Phosphoribosyl-AMP cyclohydrolase; High confidence in function and specificity; In the N-terminal section; belongs to the PRA-CH family.
  
 0.999
hisF
Imidazoleglycerol-phosphate synthase cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 
 0.999
hisA
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; [EC:5.3.1.16], subunit hisF) (IGPS subunit hisF)., Ribulose-phosphate binding barrel, Histidine biosynthesis protein, TIGR00007: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; High confidence in function and specificity.
 
  
 0.999
hisH
Amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
 0.999
hisD
HisD protein; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
  
 0.999
hisG
HisG protein; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
 
  
 0.999
hisC
PF00155: Aminotransferase class I and II, TIGR01141: histidinol-phosphate aminotransferase; High confidence in function and specificity; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
 
 0.999
llmg_2345
TIGR01656 : histidinol-phosphate phosphatase family domain, hisB like protein; High confidence in function and specificity.
 
 
  
 0.982
hisZ
HisZ protein; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
  
  
 0.958
hisK
Histidinol-phosphatase; IPR010140: Histidinol phosphate phosphatase, HisJ, TIGR01856: histidinol phosphate phosphatase HisJ family; High confidence in function and specificity; Belongs to the PHP hydrolase family. HisK subfamily.
  
  
 0.926
Your Current Organism:
Lactococcus lactis
NCBI taxonomy Id: 416870
Other names: L. lactis subsp. cremoris MG1363, Lactococcus lactis subsp. cremoris MG1363, Lactococcus lactis subsp. cremoris str. MG1363, Lactococcus lactis subsp. cremoris strain MG1363
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