node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
dnaD | llmg_1499 | llmg_1502 | llmg_1499 | DnaD-like domain; High confidence in function and specificity. | Conserved hypothetical protein; NIF3 (NGG1p interacting factor 3) like protein. | 0.764 |
dnaD | llmg_1500 | llmg_1502 | llmg_1500 | DnaD-like domain; High confidence in function and specificity. | Similar to SAM-dependent methyltransferases; Conserved hypothetical protein. | 0.793 |
dnaD | nth | llmg_1502 | llmg_1501 | DnaD-like domain; High confidence in function and specificity. | Putative endonuclease III (DNA repair); DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.885 |
exoA | mutY | llmg_1765 | llmg_1717 | 3'-exo-deoxyribonuclease; Exodeoxyribonuclease A; High confidence in function and specificity. | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. | 0.820 |
exoA | nth | llmg_1765 | llmg_1501 | 3'-exo-deoxyribonuclease; Exodeoxyribonuclease A; High confidence in function and specificity. | Putative endonuclease III (DNA repair); DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.986 |
exoA | polA | llmg_1765 | llmg_2425 | 3'-exo-deoxyribonuclease; Exodeoxyribonuclease A; High confidence in function and specificity. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity. | 0.999 |
exoA | ung | llmg_1765 | llmg_0244 | 3'-exo-deoxyribonuclease; Exodeoxyribonuclease A; High confidence in function and specificity. | Pseudogene; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. | 0.720 |
fpg | mutT | llmg_0373 | llmg_2510 | Fpg protein; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | Putative mutator protein; ADP-ribose pyrophosphatase (EC 3.6.1.13) (ADP-ribose diphosphatase) (Adenosine diphosphoribose pyrophosphatase) (ADPR-PPase) (ADP-ribose phosphohydrolase)., NUDIX hydrolase, NUDIX domain; High confidence in function and specificity; Belongs to the Nudix hydrolase family. | 0.908 |
fpg | mutY | llmg_0373 | llmg_1717 | Fpg protein; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. | 0.972 |
fpg | nth | llmg_0373 | llmg_1501 | Fpg protein; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | Putative endonuclease III (DNA repair); DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.981 |
fpg | polA | llmg_0373 | llmg_2425 | Fpg protein; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity. | 0.983 |
fpg | ung | llmg_0373 | llmg_0244 | Fpg protein; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | Pseudogene; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. | 0.661 |
gpo | nth | llmg_1088 | llmg_1501 | Gpo protein; High confidence in function and specificity. | Putative endonuclease III (DNA repair); DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.562 |
llmg_1499 | dnaD | llmg_1499 | llmg_1502 | Conserved hypothetical protein; NIF3 (NGG1p interacting factor 3) like protein. | DnaD-like domain; High confidence in function and specificity. | 0.764 |
llmg_1499 | llmg_1500 | llmg_1499 | llmg_1500 | Conserved hypothetical protein; NIF3 (NGG1p interacting factor 3) like protein. | Similar to SAM-dependent methyltransferases; Conserved hypothetical protein. | 0.987 |
llmg_1499 | nth | llmg_1499 | llmg_1501 | Conserved hypothetical protein; NIF3 (NGG1p interacting factor 3) like protein. | Putative endonuclease III (DNA repair); DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.785 |
llmg_1500 | dnaD | llmg_1500 | llmg_1502 | Similar to SAM-dependent methyltransferases; Conserved hypothetical protein. | DnaD-like domain; High confidence in function and specificity. | 0.793 |
llmg_1500 | llmg_1499 | llmg_1500 | llmg_1499 | Similar to SAM-dependent methyltransferases; Conserved hypothetical protein. | Conserved hypothetical protein; NIF3 (NGG1p interacting factor 3) like protein. | 0.987 |
llmg_1500 | nth | llmg_1500 | llmg_1501 | Similar to SAM-dependent methyltransferases; Conserved hypothetical protein. | Putative endonuclease III (DNA repair); DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.785 |
llmg_1500 | polA | llmg_1500 | llmg_2425 | Similar to SAM-dependent methyltransferases; Conserved hypothetical protein. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity. | 0.420 |