STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pyrEPyrE protein; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (209 aa)    
Predicted Functional Partners:
pyrF
Orotidine-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.
 
 0.999
pyrK
Dihydroorotate dehydrogenase, electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrDB subunit to the ultimate electron acceptor NAD(+).
  
 
 0.992
pyrB
Aspartate carbamoyltransferase; High confidence in function and specificity; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
 
  
 0.981
pyrDB
PyrDB protein; Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor. Cannot use fumarate as an electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
 
 0.979
pyrC
Putative dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
 
  
 0.975
pyrDA
Dihydroorotate dehydrogenase A; Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro, but cannot use NAD(+) as an electron acceptor.
  
 0.969
pyrR
Pyrimidine operon attenuation protein / uracil phosphoribosyltransferase; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines, probably by binding to specific sites on pyr mRNA. This probably disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes.
  
  
 0.952
carB
Carbamoyl-phosphate synthase, large subunit; Region start changed from 1046934 to 1046961 (-27 bases); Belongs to the CarB family.
  
 
 0.932
pyrP
Uracil permease (Uracil transporter); High confidence in function and specificity.
  
  
 0.905
carA
Carbamoyl-phosphate synthase small chain; High confidence in function and specificity; Belongs to the CarA family.
  
  
 0.880
Your Current Organism:
Lactococcus lactis
NCBI taxonomy Id: 416870
Other names: L. lactis subsp. cremoris MG1363, Lactococcus lactis subsp. cremoris MG1363, Lactococcus lactis subsp. cremoris str. MG1363, Lactococcus lactis subsp. cremoris strain MG1363
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