node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
acpS | alr | llmg_1705 | llmg_1704 | Holo-[acyl-carrier protein] synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. | Alr protein; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids. | 0.917 |
acpS | dltC | llmg_1705 | llmg_1221 | Holo-[acyl-carrier protein] synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. | D-alanyl carrier protein; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. | 0.644 |
alr | acpS | llmg_1704 | llmg_1705 | Alr protein; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids. | Holo-[acyl-carrier protein] synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. | 0.917 |
alr | aspC | llmg_1704 | llmg_0171 | Alr protein; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids. | Aspartate aminotransferase, Transaminase A (ASPAT), Aminotransferase, class I and II; High confidence in function and specificity. | 0.896 |
alr | ceo | llmg_1704 | llmg_1237 | Alr protein; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids. | N5-carboxyethyl-ornithine synthase; High confidence in function and specificity. | 0.816 |
alr | ddl | llmg_1704 | llmg_0360 | Alr protein; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids. | D-alanine-D-alanine ligase; Cell wall formation. | 0.981 |
alr | dltA | llmg_1704 | llmg_1219 | Alr protein; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids. | D-alanine-activating enzyme; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to the ATP-dependent AMP [...] | 0.936 |
alr | dltC | llmg_1704 | llmg_1221 | Alr protein; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids. | D-alanyl carrier protein; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. | 0.904 |
alr | murD | llmg_1704 | llmg_0912 | Alr protein; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids. | MurD protein; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.698 |
alr | murF | llmg_1704 | llmg_0361 | Alr protein; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids. | UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. | 0.948 |
alr | murI | llmg_1704 | llmg_1187 | Alr protein; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids. | MurI protein; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.590 |
alr | thyA | llmg_1704 | llmg_0964 | Alr protein; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids. | ThyA protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.816 |
aspC | alr | llmg_0171 | llmg_1704 | Aspartate aminotransferase, Transaminase A (ASPAT), Aminotransferase, class I and II; High confidence in function and specificity. | Alr protein; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids. | 0.896 |
aspC | ddl | llmg_0171 | llmg_0360 | Aspartate aminotransferase, Transaminase A (ASPAT), Aminotransferase, class I and II; High confidence in function and specificity. | D-alanine-D-alanine ligase; Cell wall formation. | 0.512 |
ceo | alr | llmg_1237 | llmg_1704 | N5-carboxyethyl-ornithine synthase; High confidence in function and specificity. | Alr protein; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids. | 0.816 |
ddl | alr | llmg_0360 | llmg_1704 | D-alanine-D-alanine ligase; Cell wall formation. | Alr protein; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids. | 0.981 |
ddl | aspC | llmg_0360 | llmg_0171 | D-alanine-D-alanine ligase; Cell wall formation. | Aspartate aminotransferase, Transaminase A (ASPAT), Aminotransferase, class I and II; High confidence in function and specificity. | 0.512 |
ddl | dltA | llmg_0360 | llmg_1219 | D-alanine-D-alanine ligase; Cell wall formation. | D-alanine-activating enzyme; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to the ATP-dependent AMP [...] | 0.918 |
ddl | dltC | llmg_0360 | llmg_1221 | D-alanine-D-alanine ligase; Cell wall formation. | D-alanyl carrier protein; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. | 0.904 |
ddl | murD | llmg_0360 | llmg_0912 | D-alanine-D-alanine ligase; Cell wall formation. | MurD protein; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.820 |