STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
menXMenaquinone biosynthesis related protein; Catalyzes a proton abstraction reaction that results in 2,5- elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6- hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). (271 aa)    
Predicted Functional Partners:
menD
2-oxoglutarate decarboxylase / 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
 
 0.999
menC
O-succinylbenzoate synthase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
 
  
 0.993
menB
Naphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA).
 
  
 0.973
menF
Menaquinone-specific isochorismate synthase; High confidence in function and specificity.
 
  
 0.953
ubiA
Putative prenyltransferase, UbiA family; Probable 1,4-dihydroxy-2-naphthoate octaprenyltransferase; High confidence in function and specificity.
 
 
 
 0.888
menA
Prenyltransferase, UbiA family; Probable 1,4-dihydroxy-2-naphthoate octaprenyltransferase, DHNA-octaprenyltransferase, UbiA prenyltransferase; High confidence in function and specificity.
 
 
 
 0.887
menE
O-succinylbenzoic acid--CoA ligase; Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA); Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily.
 
 
 0.814
cydD
Cytochrome D ABC transporter ATP binding and permease protein; Involved in the cytochrome D branch of aerobic respiration; High confidence in function and specificity.
      
 0.726
cydC
Cytochrome D ABC transporter ATP binding and permease protein; Involved in the cytochrome D branch of aerobic respiration; High confidence in function and specificity.
      
 0.726
ispB
Similar to heptaprenyl diphosphate synthase component II; High confidence in function and specificity; Belongs to the FPP/GGPP synthase family.
  
 
 0.719
Your Current Organism:
Lactococcus lactis
NCBI taxonomy Id: 416870
Other names: L. lactis subsp. cremoris MG1363, Lactococcus lactis subsp. cremoris MG1363, Lactococcus lactis subsp. cremoris str. MG1363, Lactococcus lactis subsp. cremoris strain MG1363
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