STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
glnRGlutamine synthetase repressor; GLNR, MerR family transcriptional regulator; High confidence in function and specificity. (121 aa)    
Predicted Functional Partners:
glnA
GlnA protein; PF00120: Glutamine synthetase, catalytic domain, TIGR00653: glutamine synthetase, type I; High confidence in function and specificity.
 
 
 0.973
codY
Transcriptional regulator; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family.
      
 0.811
treR
Trehalose operon transcriptional repressor; GntR family transcriptional regulator; Conserved hypothetical protein.
   
  
 0.746
glnQ
Glutamine ABC transporter ATP-binding protein; High confidence in function and specificity.
   
  
 0.680
amtB
Ammonium transporter AmtB; High confidence in function and specificity.
  
  
 0.671
ccpA
Catabolite control protein A; High confidence in function and specificity.
      
 0.570
dnaJ
Chaperone protein dnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
  
 
 0.568
ptpL
Protein-tyrosine phosphatase; PF01451: Low molecular weight phosphotyrosine protein phosphatase; High confidence in function and specificity.
       0.527
llmg_1812
Putative kinase; Phosphotransferase enzyme family, Similar to choline kinases involved in LPS biosynthesis.
  
     0.522
copR
Transcriptional regulator; High confidence in function and specificity.
     
 0.491
Your Current Organism:
Lactococcus lactis
NCBI taxonomy Id: 416870
Other names: L. lactis subsp. cremoris MG1363, Lactococcus lactis subsp. cremoris MG1363, Lactococcus lactis subsp. cremoris str. MG1363, Lactococcus lactis subsp. cremoris strain MG1363
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