jhhlp_007645 protein (Lomentospora prolificans)

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second shell of interactors

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filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

jhhlp_007645

SGF29 C-terminal domain-containing protein. (458 aa)

Predicted Functional Partners:

jhhlp_002982

0.997

jhhlp_002605

0.996

jhhlp_002629

0.996

jhhlp_000913

0.996

jhhlp_001038

0.996

jhhlp_001024

0.996

jhhlp_005990

0.995

jhhlp_003680

0.995

jhhlp_002975

0.990

jhhlp_000551

0.987

Your Current Organism:

Lomentospora prolificans

NCBI taxonomy Id: 41688
Other names: CBS 467.74, IMI 188615, L. prolificans, MUCL 18141, Scedosporium inflatum, Scedosporium prolificans

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
jhhlp_000551	jhhlp_000913	A0A2N3NL73	A0A2N3NJS8	Uncharacterized protein.	Uncharacterized protein.	0.733
jhhlp_000551	jhhlp_001024	A0A2N3NL73	A0A2N3NKC8	Uncharacterized protein.	Uncharacterized protein.	0.723
jhhlp_000551	jhhlp_001038	A0A2N3NL73	A0A2N3NK48	Uncharacterized protein.	Uncharacterized protein.	0.852
jhhlp_000551	jhhlp_002605	A0A2N3NL73	A0A2N3NEI4	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.821
jhhlp_000551	jhhlp_002629	A0A2N3NL73	A0A2N3NET3	Uncharacterized protein.	Ubiquitinyl hydrolase 1.	0.815
jhhlp_000551	jhhlp_002975	A0A2N3NL73	A0A2N3NFK0	Uncharacterized protein.	Bromo domain-containing protein.	0.733
jhhlp_000551	jhhlp_002982	A0A2N3NL73	A0A2N3NFN9	Uncharacterized protein.	TFIID_20kDa domain-containing protein.	0.852
jhhlp_000551	jhhlp_003680	A0A2N3NL73	A0A2N3N9I7	Uncharacterized protein.	Uncharacterized protein.	0.915
jhhlp_000551	jhhlp_005990	A0A2N3NL73	A0A2N3N4N7	Uncharacterized protein.	Transcriptional adapter 2; Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation.	0.963
jhhlp_000551	jhhlp_007645	A0A2N3NL73	A0A2N3N060	Uncharacterized protein.	SGF29 C-terminal domain-containing protein.	0.987
jhhlp_000913	jhhlp_000551	A0A2N3NJS8	A0A2N3NL73	Uncharacterized protein.	Uncharacterized protein.	0.733
jhhlp_000913	jhhlp_001024	A0A2N3NJS8	A0A2N3NKC8	Uncharacterized protein.	Uncharacterized protein.	0.990
jhhlp_000913	jhhlp_001038	A0A2N3NJS8	A0A2N3NK48	Uncharacterized protein.	Uncharacterized protein.	0.998
jhhlp_000913	jhhlp_002605	A0A2N3NJS8	A0A2N3NEI4	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.995
jhhlp_000913	jhhlp_002629	A0A2N3NJS8	A0A2N3NET3	Uncharacterized protein.	Ubiquitinyl hydrolase 1.	0.992
jhhlp_000913	jhhlp_002975	A0A2N3NJS8	A0A2N3NFK0	Uncharacterized protein.	Bromo domain-containing protein.	0.972
jhhlp_000913	jhhlp_002982	A0A2N3NJS8	A0A2N3NFN9	Uncharacterized protein.	TFIID_20kDa domain-containing protein.	0.977
jhhlp_000913	jhhlp_003680	A0A2N3NJS8	A0A2N3N9I7	Uncharacterized protein.	Uncharacterized protein.	0.987
jhhlp_000913	jhhlp_005990	A0A2N3NJS8	A0A2N3N4N7	Uncharacterized protein.	Transcriptional adapter 2; Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation.	0.997
jhhlp_000913	jhhlp_007645	A0A2N3NJS8	A0A2N3N060	Uncharacterized protein.	SGF29 C-terminal domain-containing protein.	0.996

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

26

average node degree:

4.73

avg. local clustering coefficient:

0.842

expected number of edges:

12

PPI enrichment p-value:

0.000188

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009395

Phospholipid catabolic process

3 of 11

2.34

1.91

0.00025

GO:0046486

Glycerolipid metabolic process

5 of 102

1.6

1.65

0.00012

GO:0016042

Lipid catabolic process

5 of 104

1.59

1.64

0.00012

GO:0006644

Phospholipid metabolic process

5 of 126

1.51

1.5

0.00019

GO:0006650

Glycerophospholipid metabolic process

4 of 91

1.55

1.27

0.0013

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004691

cAMP-dependent protein kinase activity

3 of 4

2.78

2.32

5.69e-05

GO:0016298

Lipase activity

4 of 39

1.92

2.03

5.69e-05

GO:0004620

Phospholipase activity

3 of 16

2.18

1.81

0.00033

GO:0052689

Carboxylic ester hydrolase activity

4 of 65

1.7

1.59

0.00031

GO:0004679

AMP-activated protein kinase activity

2 of 2

2.91

1.52

0.0018

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:11877

Glycerophospholipid metabolism, and Triglyceride metabolic process

5 of 67

1.78

2.08

2.15e-05

CL:3125

DARPP-32 events, and G protein activity

3 of 11

2.34

1.96

0.00020

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00564

Glycerophospholipid metabolism

7 of 94

1.78

3.38

9.54e-10

map00565

Ether lipid metabolism

3 of 28

1.94

1.65

0.00048

map00591

Linoleic acid metabolism

2 of 9

2.25

1.29

0.0039

map00590

Arachidonic acid metabolism

2 of 18

1.95

1.04

0.0100

map00592

alpha-Linolenic acid metabolism

2 of 27

1.78

0.9

0.0170

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-111996

Ca-dependent events

4 of 7

2.66

3.42

3.85e-07

MAP-112043

PLC beta mediated events

4 of 9

2.56

3.37

4.17e-07

MAP-112040

G-protein mediated events

4 of 9

2.56

3.37

4.17e-07

MAP-111885

Opioid Signalling

4 of 10

2.51

3.34

4.17e-07

MAP-418594

G alpha (i) signalling events

4 of 14

2.36

3.16

7.12e-07

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005952

cAMP-dependent protein kinase complex

3 of 5

2.69

2.23

7.67e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0442

Lipid degradation

4 of 11

2.47

3.33

4.06e-07

KW-0378

Hydrolase

4 of 341

0.98

0.51

0.0466

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03009

Glycerophosphoryl diester phosphodiesterase family

2 of 4

2.61

0.95

0.0188

PF01734

Patatin-like phospholipase

2 of 6

2.43

0.94

0.0188

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR016035

Acyl transferase/acyl hydrolase/lysophospholipase

4 of 14

2.36

2.61

1.00e-05

IPR002642

Lysophospholipase, catalytic domain

2 of 2

2.91

1.09

0.0109

IPR030395

Glycerophosphodiester phosphodiesterase domain

2 of 4

2.61

0.96

0.0182

IPR002641

Patatin-like phospholipase domain

2 of 6

2.43

0.87

0.0254

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00022

Cytoplasmic phospholipase A2, catalytic subunit

2 of 2

2.91

1.43

0.0026

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