jhhlp_005359 protein (Lomentospora prolificans)

Nodes:

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

jhhlp_005359

Uncharacterized protein. (203 aa)

Predicted Functional Partners:

jhhlp_002283

0.983

jhhlp_001271

0.983

jhhlp_003705

0.946

jhhlp_002129

0.909

jhhlp_000468

0.904

jhhlp_005235

0.897

jhhlp_002359

0.897

jhhlp_006021

0.882

jhhlp_004284

0.803

jhhlp_003874

0.777

Your Current Organism:

Lomentospora prolificans

NCBI taxonomy Id: 41688
Other names: CBS 467.74, IMI 188615, L. prolificans, MUCL 18141, Scedosporium inflatum, Scedosporium prolificans

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
jhhlp_000468	jhhlp_001271	A0A2N3NKX8	A0A2N3NHR2	Uncharacterized protein.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	0.895
jhhlp_000468	jhhlp_002129	A0A2N3NKX8	A0A2N3ND73	Uncharacterized protein.	Uncharacterized protein.	0.965
jhhlp_000468	jhhlp_002283	A0A2N3NKX8	A0A2N3NDJ8	Uncharacterized protein.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.895
jhhlp_000468	jhhlp_003705	A0A2N3NKX8	A0A2N3N9J2	Uncharacterized protein.	Uncharacterized protein.	0.434
jhhlp_000468	jhhlp_005235	A0A2N3NKX8	A0A2N3N780	Uncharacterized protein.	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.657
jhhlp_000468	jhhlp_005359	A0A2N3NKX8	A0A2N3N6P3	Uncharacterized protein.	Uncharacterized protein.	0.904
jhhlp_000468	jhhlp_006021	A0A2N3NKX8	A0A2N3N4R3	Uncharacterized protein.	HORMA domain-containing protein.	0.879
jhhlp_001271	jhhlp_000468	A0A2N3NHR2	A0A2N3NKX8	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	Uncharacterized protein.	0.895
jhhlp_001271	jhhlp_002129	A0A2N3NHR2	A0A2N3ND73	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	Uncharacterized protein.	0.906
jhhlp_001271	jhhlp_002283	A0A2N3NHR2	A0A2N3NDJ8	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.770
jhhlp_001271	jhhlp_002359	A0A2N3NHR2	A0A2N3NDS5	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	Uncharacterized protein.	0.965
jhhlp_001271	jhhlp_003705	A0A2N3NHR2	A0A2N3N9J2	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	Uncharacterized protein.	0.977
jhhlp_001271	jhhlp_003874	A0A2N3NHR2	A0A2N3NA00	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	Uncharacterized protein.	0.655
jhhlp_001271	jhhlp_004284	A0A2N3NHR2	A0A2N3NB58	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	Histone H3; Belongs to the histone H3 family.	0.602
jhhlp_001271	jhhlp_005235	A0A2N3NHR2	A0A2N3N780	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.906
jhhlp_001271	jhhlp_005359	A0A2N3NHR2	A0A2N3N6P3	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	Uncharacterized protein.	0.983
jhhlp_001271	jhhlp_006021	A0A2N3NHR2	A0A2N3N4R3	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	HORMA domain-containing protein.	0.459
jhhlp_002129	jhhlp_000468	A0A2N3ND73	A0A2N3NKX8	Uncharacterized protein.	Uncharacterized protein.	0.965
jhhlp_002129	jhhlp_001271	A0A2N3ND73	A0A2N3NHR2	Uncharacterized protein.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	0.906
jhhlp_002129	jhhlp_002283	A0A2N3ND73	A0A2N3NDJ8	Uncharacterized protein.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.906

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

35

average node degree:

6.36

avg. local clustering coefficient:

0.852

expected number of edges:

24

PPI enrichment p-value:

0.0189

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006260

DNA replication

4 of 38

1.26

0.89

0.0056

GO:0090304

Nucleic acid metabolic process

10 of 248

0.84

0.82

1.68e-05

GO:0006259

DNA metabolic process

6 of 128

0.9

0.67

0.0044

GO:0009059

Macromolecule biosynthetic process

6 of 166

0.79

0.53

0.0123

GO:0044260

Cellular macromolecule metabolic process

8 of 295

0.67

0.49

0.0044

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140640

Catalytic activity, acting on a nucleic acid

9 of 154

1.0

1.08

4.70e-06

GO:0016779

Nucleotidyltransferase activity

4 of 31

1.34

1.06

0.0023

GO:0003677

DNA binding

9 of 185

0.92

0.94

1.13e-05

GO:0003697

Single-stranded DNA binding

2 of 4

1.93

0.85

0.0238

GO:0140097

Catalytic activity, acting on DNA

5 of 73

1.07

0.83

0.0027

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0061695

Transferase complex, transferring phosphorus-containing groups

3 of 10

1.71

1.19

0.0034

GO:0000428

DNA-directed RNA polymerase complex

2 of 5

1.84

0.96

0.0133

GO:0140535

Intracellular protein-containing complex

3 of 20

1.41

0.95

0.0068

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:556

Mixed, incl. DNA replication, and Nucleotide excision repair

5 of 29

1.47

1.44

0.00024

CL:551

Mixed, incl. Catalytic activity, acting on DNA, and DNA replication

6 of 68

1.18

1.13

0.00024

CL:323

tRNA aminoacylation

3 of 15

1.53

0.95

0.0094

CL:558

Mixed, incl. Nucleotide excision repair, and Mre11 nuclease, N-terminal metallophosphatase domain

3 of 18

1.46

0.87

0.0126

CL:215

RNA polymerase

2 of 5

1.84

0.77

0.0328

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03030

DNA replication

4 of 22

1.49

1.3

0.00083

map03440

Homologous recombination

4 of 31

1.34

1.12

0.0014

map03020

RNA polymerase

2 of 4

1.93

0.96

0.0146

map03430

Mismatch repair

3 of 27

1.28

0.78

0.0146

map03410

Base excision repair

2 of 10

1.53

0.7

0.0377

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0548

Nucleotidyltransferase

4 of 21

1.51

1.27

0.0011

KW-0235

DNA replication

3 of 14

1.56

1.02

0.0065

KW-0240

DNA-directed RNA polymerase

2 of 5

1.84

0.92

0.0163

KW-0239

DNA-directed DNA polymerase

2 of 5

1.84

0.92

0.0163

KW-0234

DNA repair

3 of 23

1.35

0.82

0.0136

(more ...)

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