jhhlp_005436 protein (Lomentospora prolificans)

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second shell of interactors

Node Content

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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[Homology]

Score

jhhlp_005436

Uncharacterized protein. (687 aa)

Predicted Functional Partners:

jhhlp_007735

0.575

jhhlp_005609

0.474

jhhlp_001137

0.474

jhhlp_004189

0.466

jhhlp_000261

0.466

jhhlp_000235

0.465

jhhlp_005206

0.464

jhhlp_005205

0.464

jhhlp_006390

0.458

jhhlp_002197

0.456

Your Current Organism:

Lomentospora prolificans

NCBI taxonomy Id: 41688
Other names: CBS 467.74, IMI 188615, L. prolificans, MUCL 18141, Scedosporium inflatum, Scedosporium prolificans

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
jhhlp_000235	jhhlp_005436	A0A2N3NKC4	A0A2N3N6T4	Uncharacterized protein.	Uncharacterized protein.	0.465
jhhlp_000261	jhhlp_001137	A0A2N3NKG3	A0A2N3NHD7	Uncharacterized protein; Belongs to the SKP1 family.	Ubiquitin-like domain-containing protein.	0.529
jhhlp_000261	jhhlp_005205	A0A2N3NKG3	A0A2N3N7A6	Uncharacterized protein; Belongs to the SKP1 family.	Uncharacterized protein.	0.781
jhhlp_000261	jhhlp_005206	A0A2N3NKG3	A0A2N3N745	Uncharacterized protein; Belongs to the SKP1 family.	MPN domain-containing protein.	0.781
jhhlp_000261	jhhlp_005436	A0A2N3NKG3	A0A2N3N6T4	Uncharacterized protein; Belongs to the SKP1 family.	Uncharacterized protein.	0.466
jhhlp_000261	jhhlp_006390	A0A2N3NKG3	A0A2N3N5Y2	Uncharacterized protein; Belongs to the SKP1 family.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.711
jhhlp_000261	jhhlp_007735	A0A2N3NKG3	A0A2N3N0E8	Uncharacterized protein; Belongs to the SKP1 family.	ANK_REP_REGION domain-containing protein.	0.550
jhhlp_001137	jhhlp_000261	A0A2N3NHD7	A0A2N3NKG3	Ubiquitin-like domain-containing protein.	Uncharacterized protein; Belongs to the SKP1 family.	0.529
jhhlp_001137	jhhlp_002197	A0A2N3NHD7	A0A2N3NDA6	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.722
jhhlp_001137	jhhlp_004189	A0A2N3NHD7	A0A2N3NB14	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.529
jhhlp_001137	jhhlp_005205	A0A2N3NHD7	A0A2N3N7A6	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.727
jhhlp_001137	jhhlp_005206	A0A2N3NHD7	A0A2N3N745	Ubiquitin-like domain-containing protein.	MPN domain-containing protein.	0.727
jhhlp_001137	jhhlp_005436	A0A2N3NHD7	A0A2N3N6T4	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.474
jhhlp_001137	jhhlp_006390	A0A2N3NHD7	A0A2N3N5Y2	Ubiquitin-like domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.999
jhhlp_001137	jhhlp_007735	A0A2N3NHD7	A0A2N3N0E8	Ubiquitin-like domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.799
jhhlp_002197	jhhlp_001137	A0A2N3NDA6	A0A2N3NHD7	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.722
jhhlp_002197	jhhlp_005205	A0A2N3NDA6	A0A2N3N7A6	Uncharacterized protein.	Uncharacterized protein.	0.406
jhhlp_002197	jhhlp_005206	A0A2N3NDA6	A0A2N3N745	Uncharacterized protein.	MPN domain-containing protein.	0.406
jhhlp_002197	jhhlp_005436	A0A2N3NDA6	A0A2N3N6T4	Uncharacterized protein.	Uncharacterized protein.	0.456
jhhlp_002197	jhhlp_005609	A0A2N3NDA6	A0A2N3N3M9	Uncharacterized protein.	MRG domain-containing protein.	0.790

page 1 of 4

Network Stats

number of nodes:

7

number of edges:

13

average node degree:

3.71

avg. local clustering coefficient:

0.819

expected number of edges:

6

PPI enrichment p-value:

0.0103

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009082

Branched-chain amino acid biosynthetic process

9 of 15

2.47

8.0

8.49e-18

GO:0009098

Leucine biosynthetic process

5 of 5

2.69

5.0

2.91e-10

GO:0009097

Isoleucine biosynthetic process

5 of 11

2.35

4.17

4.08e-09

GO:0009099

Valine biosynthetic process

4 of 5

2.59

3.75

7.65e-08

GO:1901607

Alpha-amino acid biosynthetic process

9 of 85

1.71

3.74

2.25e-12

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003984

Acetolactate synthase activity

2 of 3

2.51

1.11

0.0095

GO:0003861

3-isopropylmalate dehydratase activity

2 of 2

2.69

1.11

0.0095

GO:0003852

2-isopropylmalate synthase activity

2 of 2

2.69

1.11

0.0095

GO:0016836

Hydro-lyase activity

3 of 30

1.69

0.99

0.0095

GO:0000287

Magnesium ion binding

4 of 74

1.42

0.9

0.0095

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005829

Cytosol

5 of 294

0.92

0.63

0.0090

GO:0005737

Cytoplasm

10 of 1367

0.55

0.44

0.0015

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:32786290

(2020) Cyanobacterial Dihydroxyacid Dehydratases Are a Promising Growth Inhibition Target.

4 of 5

2.59

3.1

1.49e-06

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5042

Valine, leucine and isoleucine biosynthesis

9 of 11

2.6

8.74

1.05e-18

CL:5043

Leucine metabolic process

5 of 6

2.61

4.69

9.53e-10

CL:5054

Valine metabolic process

4 of 5

2.59

3.57

1.75e-07

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ana00290

Valine, leucine and isoleucine biosynthesis

10 of 14

2.54

9.93

4.27e-22

ana01210

2-Oxocarboxylic acid metabolism

9 of 23

2.28

7.37

8.16e-18

ana00660

C5-Branched dibasic acid metabolism

5 of 8

2.48

4.79

3.47e-10

ana00770

Pantothenate and CoA biosynthesis

5 of 15

2.21

4.03

3.46e-09

ana01230

Biosynthesis of amino acids

9 of 117

1.57

3.22

2.32e-12

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009316

3-isopropylmalate dehydratase complex

2 of 2

2.69

1.46

0.0022

GOCC:0005948

Acetolactate synthase complex

2 of 4

2.39

1.29

0.0041

GOCC:0005737

Cytoplasm

10 of 989

0.69

0.61

0.00013

GOCC:1902494

Catalytic complex

4 of 217

0.95

0.51

0.0425

GOCC:0005622

Intracellular

11 of 1555

0.54

0.46

0.00018

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0100

Branched-chain amino acid biosynthesis

8 of 10

2.59

7.88

9.72e-17

KW-0432

Leucine biosynthesis

4 of 4

2.69

3.88

5.15e-08

KW-0460

Magnesium

4 of 116

1.23

0.94

0.0032

KW-0479

Metal-binding

6 of 303

0.99

0.85

0.00072

KW-0456

Lyase

3 of 90

1.21

0.65

0.0291

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00682

HMGL-like

2 of 4

2.39

0.76

0.0417

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036230

2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain superfamily

2 of 2

2.69

0.76

0.0425

IPR013709

2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain

2 of 2

2.69

0.76

0.0425

IPR002034

Alpha-isopropylmalate/homocitrate synthase, conserved site

2 of 4

2.39

0.75

0.0425

IPR000891

Pyruvate carboxyltransferase

2 of 4

2.39

0.75

0.0425

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00917

LeuA allosteric (dimerisation) domain

2 of 2

2.69

1.36

0.0033

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