jhhlp_004744 protein (Lomentospora prolificans)

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

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[Homology]

Score

jhhlp_004744

WD_REPEATS_REGION domain-containing protein. (1628 aa)

Predicted Functional Partners:

jhhlp_008064

0.999

jhhlp_006755

0.999

jhhlp_005560

0.999

jhhlp_003593

0.999

jhhlp_002835

0.999

jhhlp_000435

0.999

jhhlp_007268

0.998

jhhlp_007403

0.998

jhhlp_003515

0.998

jhhlp_002217

0.998

Your Current Organism:

Lomentospora prolificans

NCBI taxonomy Id: 41688
Other names: CBS 467.74, IMI 188615, L. prolificans, MUCL 18141, Scedosporium inflatum, Scedosporium prolificans

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
jhhlp_000435	jhhlp_002217	A0A2N3NKY5	A0A2N3NDC5	MPN domain-containing protein.	Uncharacterized protein.	0.996
jhhlp_000435	jhhlp_002835	A0A2N3NKY5	A0A2N3NF63	MPN domain-containing protein.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.999
jhhlp_000435	jhhlp_003515	A0A2N3NKY5	A0A2N3N954	MPN domain-containing protein.	Proteasome endopeptidase complex.	0.999
jhhlp_000435	jhhlp_003593	A0A2N3NKY5	A0A2N3N970	MPN domain-containing protein.	26S proteasome regulatory subunit RPN1; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.	0.999
jhhlp_000435	jhhlp_004744	A0A2N3NKY5	A0A2N3N8A7	MPN domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.999
jhhlp_000435	jhhlp_005560	A0A2N3NKY5	A0A2N3N3H6	MPN domain-containing protein.	PCI domain-containing protein.	0.999
jhhlp_000435	jhhlp_006755	A0A2N3NKY5	A0A2N3N2M3	MPN domain-containing protein.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.999
jhhlp_000435	jhhlp_007268	A0A2N3NKY5	A0A2N3N269	MPN domain-containing protein.	VWFA domain-containing protein.	0.999
jhhlp_000435	jhhlp_007403	A0A2N3NKY5	A0A2N3N2K7	MPN domain-containing protein.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.999
jhhlp_000435	jhhlp_008064	A0A2N3NKY5	A0A2N3MZD9	MPN domain-containing protein.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.999
jhhlp_002217	jhhlp_000435	A0A2N3NDC5	A0A2N3NKY5	Uncharacterized protein.	MPN domain-containing protein.	0.996
jhhlp_002217	jhhlp_002835	A0A2N3NDC5	A0A2N3NF63	Uncharacterized protein.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.998
jhhlp_002217	jhhlp_003515	A0A2N3NDC5	A0A2N3N954	Uncharacterized protein.	Proteasome endopeptidase complex.	0.983
jhhlp_002217	jhhlp_003593	A0A2N3NDC5	A0A2N3N970	Uncharacterized protein.	26S proteasome regulatory subunit RPN1; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.	0.997
jhhlp_002217	jhhlp_004744	A0A2N3NDC5	A0A2N3N8A7	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.998
jhhlp_002217	jhhlp_005560	A0A2N3NDC5	A0A2N3N3H6	Uncharacterized protein.	PCI domain-containing protein.	0.997
jhhlp_002217	jhhlp_006755	A0A2N3NDC5	A0A2N3N2M3	Uncharacterized protein.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.996
jhhlp_002217	jhhlp_007268	A0A2N3NDC5	A0A2N3N269	Uncharacterized protein.	VWFA domain-containing protein.	0.999
jhhlp_002217	jhhlp_007403	A0A2N3NDC5	A0A2N3N2K7	Uncharacterized protein.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.997
jhhlp_002217	jhhlp_008064	A0A2N3NDC5	A0A2N3MZD9	Uncharacterized protein.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.985

page 1 of 6

Network Stats

number of nodes:

8

number of edges:

13

average node degree:

3.25

avg. local clustering coefficient:

0.827

expected number of edges:

9

PPI enrichment p-value:

0.117

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042773

ATP synthesis coupled electron transport

4 of 6

2.09

2.02

9.79e-05

GO:0009060

Aerobic respiration

5 of 30

1.49

1.52

0.00015

GO:0022900

Electron transport chain

5 of 57

1.21

1.04

0.0011

GO:0006091

Generation of precursor metabolites and energy

6 of 96

1.07

0.93

0.00074

GO:0015990

Electron transport coupled proton transport

2 of 3

2.09

0.81

0.0308

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0050136

NADH dehydrogenase (quinone) activity

6 of 15

1.87

2.95

1.29e-07

GO:0048038

Quinone binding

5 of 13

1.86

2.6

1.17e-06

GO:0008137

NADH dehydrogenase (ubiquinone) activity

4 of 11

1.83

2.0

4.70e-05

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:36952383

(2023) Structure of mycobacterial respiratory complex I.

3 of 5

2.05

1.33

0.0027

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1564

Oxidative phosphorylation, and Peptidase M16, N-terminal

10 of 38

1.69

3.89

8.88e-14

CL:1570

Quinone binding

6 of 11

2.01

3.71

3.56e-09

CL:1571

Proton-conducting membrane transporter, and Quinone

5 of 6

2.19

3.63

2.92e-08

CL:1630

Mixed, incl. rRNA (adenine) methyltransferase activity, and Calcineurin-like phosphoesterase

4 of 5

2.17

2.84

1.85e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

tbc00190

Oxidative phosphorylation

6 of 39

1.46

1.89

3.15e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0874

Quinone

4 of 11

1.83

1.87

0.00010

KW-1278

Translocase

3 of 13

1.63

1.15

0.0036

KW-0520

NAD

4 of 34

1.34

1.04

0.0026

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00361

Proton-conducting membrane transporter

3 of 3

2.27

1.67

0.00069

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001750

NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit

3 of 3

2.27

1.43

0.0021

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