jhhlp_003840 protein (Lomentospora prolificans)

Nodes:

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

jhhlp_003840

RING-type domain-containing protein. (558 aa)

Predicted Functional Partners:

jhhlp_003841

0.912

jhhlp_004481

0.831

jhhlp_003468

0.825

jhhlp_003257

0.819

jhhlp_003467

0.796

jhhlp_006292

0.789

jhhlp_008310

0.784

jhhlp_000192

0.784

jhhlp_003204

0.729

jhhlp_002836

0.728

Your Current Organism:

Lomentospora prolificans

NCBI taxonomy Id: 41688
Other names: CBS 467.74, IMI 188615, L. prolificans, MUCL 18141, Scedosporium inflatum, Scedosporium prolificans

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
jhhlp_000192	jhhlp_002836	A0A2N3NKG1	A0A2N3NF70	BZIP domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.953
jhhlp_000192	jhhlp_003204	A0A2N3NKG1	A0A2N3NGB3	BZIP domain-containing protein.	HECT domain-containing protein.	0.940
jhhlp_000192	jhhlp_003257	A0A2N3NKG1	A0A2N3NGC7	BZIP domain-containing protein.	Uncharacterized protein.	0.963
jhhlp_000192	jhhlp_003467	A0A2N3NKG1	A0A2N3N8T7	BZIP domain-containing protein.	Ubiquitin-like domain-containing protein.	0.982
jhhlp_000192	jhhlp_003468	A0A2N3NKG1	A0A2N3N8X8	BZIP domain-containing protein.	RRN7-type domain-containing protein.	0.993
jhhlp_000192	jhhlp_003840	A0A2N3NKG1	A0A2N3N9V3	BZIP domain-containing protein.	RING-type domain-containing protein.	0.784
jhhlp_000192	jhhlp_006292	A0A2N3NKG1	A0A2N3N5J9	BZIP domain-containing protein.	AN1-type domain-containing protein.	0.932
jhhlp_002836	jhhlp_000192	A0A2N3NF70	A0A2N3NKG1	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	BZIP domain-containing protein.	0.953
jhhlp_002836	jhhlp_003204	A0A2N3NF70	A0A2N3NGB3	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	HECT domain-containing protein.	0.975
jhhlp_002836	jhhlp_003257	A0A2N3NF70	A0A2N3NGC7	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Uncharacterized protein.	0.996
jhhlp_002836	jhhlp_003467	A0A2N3NF70	A0A2N3N8T7	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin-like domain-containing protein.	0.952
jhhlp_002836	jhhlp_003468	A0A2N3NF70	A0A2N3N8X8	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	RRN7-type domain-containing protein.	0.981
jhhlp_002836	jhhlp_003840	A0A2N3NF70	A0A2N3N9V3	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	RING-type domain-containing protein.	0.728
jhhlp_002836	jhhlp_006292	A0A2N3NF70	A0A2N3N5J9	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	AN1-type domain-containing protein.	0.957
jhhlp_002836	jhhlp_008310	A0A2N3NF70	A0A2N3MXQ1	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin-like domain-containing protein.	0.953
jhhlp_003204	jhhlp_000192	A0A2N3NGB3	A0A2N3NKG1	HECT domain-containing protein.	BZIP domain-containing protein.	0.940
jhhlp_003204	jhhlp_002836	A0A2N3NGB3	A0A2N3NF70	HECT domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.975
jhhlp_003204	jhhlp_003257	A0A2N3NGB3	A0A2N3NGC7	HECT domain-containing protein.	Uncharacterized protein.	0.995
jhhlp_003204	jhhlp_003467	A0A2N3NGB3	A0A2N3N8T7	HECT domain-containing protein.	Ubiquitin-like domain-containing protein.	0.985
jhhlp_003204	jhhlp_003468	A0A2N3NGB3	A0A2N3N8X8	HECT domain-containing protein.	RRN7-type domain-containing protein.	0.985

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

26

PPI enrichment p-value:

3.23e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006633

Fatty acid biosynthetic process

8 of 17

2.07

4.9

2.49e-12

GO:2001295

malonyl-CoA biosynthetic process

2 of 4

2.1

0.96

0.0159

GO:0044281

Small molecule metabolic process

9 of 458

0.69

0.58

0.00035

GO:0071704

Organic substance metabolic process

11 of 1212

0.36

0.29

0.0098

GO:0044238

Primary metabolic process

10 of 999

0.4

0.29

0.0198

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004312

Fatty acid synthase activity

4 of 7

2.16

2.31

2.74e-05

GO:0016747

Acyltransferase activity, transferring groups other than amino-acyl groups

5 of 41

1.48

1.52

0.00014

GO:0000036

Acyl carrier activity

2 of 2

2.4

1.02

0.0133

GO:0003989

acetyl-CoA carboxylase activity

2 of 3

2.22

1.01

0.0133

GO:0016743

Carboxyl- or carbamoyltransferase activity

2 of 5

2.0

0.93

0.0169

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009317

acetyl-CoA carboxylase complex

2 of 4

2.1

1.07

0.0096

GO:0005737

Cytoplasm

11 of 997

0.44

0.36

0.0020

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1342

Fatty acid metabolism, and Alpha/beta hydrolase fold

7 of 13

2.13

4.56

6.41e-11

CL:1345

Fatty acid metabolism

4 of 8

2.1

2.57

5.86e-06

CL:1199

Mixed, incl. Pyruvate metabolism, and Citrate cycle (TCA cycle)

8 of 91

1.34

1.94

6.37e-08

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pace01212

Fatty acid metabolism

6 of 10

2.18

4.29

5.66e-10

pace00061

Fatty acid biosynthesis

6 of 10

2.18

4.29

5.66e-10

pace00780

Biotin metabolism

4 of 11

1.96

2.46

5.80e-06

pace01100

Metabolic pathways

9 of 530

0.63

0.53

0.00035

pace01110

Biosynthesis of secondary metabolites

5 of 249

0.7

0.42

0.0351

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009317

acetyl-CoA carboxylase complex

2 of 4

2.1

0.84

0.0276

GOCC:0005737

Cytoplasm

10 of 756

0.52

0.39

0.0054

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0275

Fatty acid biosynthesis

5 of 9

2.14

3.49

4.57e-08

KW-0444

Lipid biosynthesis

6 of 21

1.85

3.07

4.33e-08

KW-0596

Phosphopantetheine

2 of 2

2.4

1.33

0.0035

KW-0012

Acyltransferase

3 of 24

1.5

1.05

0.0044

KW-0963

Cytoplasm

6 of 253

0.77

0.56

0.0057

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01039

Carboxyl transferase domain

2 of 2

2.4

0.77

0.0390

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