jhhlp_000837 protein (Lomentospora prolificans)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

jhhlp_000837

Uncharacterized protein. (485 aa)

Predicted Functional Partners:

jhhlp_008358

0.777

jhhlp_000679

0.777

jhhlp_007735

0.607

jhhlp_005371

0.601

jhhlp_006815

0.595

jhhlp_008740

0.590

jhhlp_005785

0.590

jhhlp_000115

0.590

jhhlp_004125

0.588

jhhlp_007058

0.587

Your Current Organism:

Lomentospora prolificans

NCBI taxonomy Id: 41688
Other names: CBS 467.74, IMI 188615, L. prolificans, MUCL 18141, Scedosporium inflatum, Scedosporium prolificans

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... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
jhhlp_000115	jhhlp_000837	A0A2N3NLN1	A0A2N3NJK4	Uncharacterized protein.	Uncharacterized protein.	0.590
jhhlp_000115	jhhlp_004125	A0A2N3NLN1	A0A2N3NAP6	Uncharacterized protein.	Uncharacterized protein.	0.999
jhhlp_000115	jhhlp_005785	A0A2N3NLN1	A0A2N3N426	Uncharacterized protein.	Uncharacterized protein.	0.999
jhhlp_000115	jhhlp_006815	A0A2N3NLN1	A0A2N3N2T2	Uncharacterized protein.	Uncharacterized protein.	0.999
jhhlp_000115	jhhlp_007058	A0A2N3NLN1	A0A2N3N1K4	Uncharacterized protein.	Uncharacterized protein.	0.999
jhhlp_000115	jhhlp_008740	A0A2N3NLN1	A0A2N3MYW1	Uncharacterized protein.	Uncharacterized protein; Belongs to the universal ribosomal protein uS9 family.	0.999
jhhlp_000679	jhhlp_000837	A0A2N3NJ69	A0A2N3NJK4	Uncharacterized protein.	Uncharacterized protein.	0.777
jhhlp_000679	jhhlp_007735	A0A2N3NJ69	A0A2N3N0E8	Uncharacterized protein.	ANK_REP_REGION domain-containing protein.	0.414
jhhlp_000679	jhhlp_008358	A0A2N3NJ69	A0A2N3MXU4	Uncharacterized protein.	Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.	0.968
jhhlp_000837	jhhlp_000115	A0A2N3NJK4	A0A2N3NLN1	Uncharacterized protein.	Uncharacterized protein.	0.590
jhhlp_000837	jhhlp_000679	A0A2N3NJK4	A0A2N3NJ69	Uncharacterized protein.	Uncharacterized protein.	0.777
jhhlp_000837	jhhlp_004125	A0A2N3NJK4	A0A2N3NAP6	Uncharacterized protein.	Uncharacterized protein.	0.588
jhhlp_000837	jhhlp_005371	A0A2N3NJK4	A0A2N3N6P2	Uncharacterized protein.	Uncharacterized protein.	0.601
jhhlp_000837	jhhlp_005785	A0A2N3NJK4	A0A2N3N426	Uncharacterized protein.	Uncharacterized protein.	0.590
jhhlp_000837	jhhlp_006815	A0A2N3NJK4	A0A2N3N2T2	Uncharacterized protein.	Uncharacterized protein.	0.595
jhhlp_000837	jhhlp_007058	A0A2N3NJK4	A0A2N3N1K4	Uncharacterized protein.	Uncharacterized protein.	0.587
jhhlp_000837	jhhlp_007735	A0A2N3NJK4	A0A2N3N0E8	Uncharacterized protein.	ANK_REP_REGION domain-containing protein.	0.607
jhhlp_000837	jhhlp_008358	A0A2N3NJK4	A0A2N3MXU4	Uncharacterized protein.	Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.	0.777
jhhlp_000837	jhhlp_008740	A0A2N3NJK4	A0A2N3MYW1	Uncharacterized protein.	Uncharacterized protein; Belongs to the universal ribosomal protein uS9 family.	0.590
jhhlp_004125	jhhlp_000115	A0A2N3NAP6	A0A2N3NLN1	Uncharacterized protein.	Uncharacterized protein.	0.999

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

36

average node degree:

6.55

avg. local clustering coefficient:

0.774

expected number of edges:

12

PPI enrichment p-value:

1.9e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006397

mRNA processing

6 of 248

1.61

2.0

9.76e-06

GO:0031124

mRNA 3-end processing

3 of 26

2.29

1.78

0.00042

GO:1900363

Regulation of mRNA polyadenylation

2 of 3

3.05

1.53

0.0017

GO:1903312

Negative regulation of mRNA metabolic process

2 of 4

2.93

1.52

0.0018

GO:0006396

RNA processing

7 of 628

1.28

1.42

2.78e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008143

poly(A) binding

3 of 6

2.93

2.72

1.06e-05

GO:0003723

RNA binding

9 of 681

1.35

2.06

1.03e-08

GO:0003729

mRNA binding

4 of 95

1.86

1.93

7.91e-05

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005849

mRNA cleavage factor complex

2 of 16

2.33

1.17

0.0068

GO:0005634

Nucleus

11 of 3040

0.79

1.81e-06

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10799

Mixed, incl. Zinc finger, CCHC-type superfamily, and Regulation of mRNA polyadenylation

6 of 18

2.75

6.05

2.79e-12

CL:10825

Regulation of mRNA polyadenylation, and Importin beta family

4 of 5

3.13

4.36

1.09e-08

CL:5141

mRNA polyadenylation

2 of 5

2.83

1.23

0.0059

CL:10804

Mixed, incl. K Homology domain, type 1, and Heterokaryon incompatibility Het-C

2 of 7

2.69

1.17

0.0076

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03015

mRNA surveillance pathway

3 of 113

1.66

1.08

0.0056

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72203

Processing of Capped Intron-Containing Pre-mRNA

6 of 236

1.64

2.23

1.84e-06

MAP-73856

RNA Polymerase II Transcription Termination

3 of 41

2.1

1.65

0.00063

MAP-8953854

Metabolism of RNA

7 of 679

1.24

1.43

1.20e-05

MAP-77595

Processing of Intronless Pre-mRNAs

2 of 19

2.25

0.97

0.0158

MAP-75067

Processing of Capped Intronless Pre-mRNA

2 of 26

2.12

0.92

0.0189

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005849

mRNA cleavage factor complex

3 of 16

2.5

2.34

4.21e-05

GOCC:0005634

Nucleus

11 of 1725

1.04

1.32

4.36e-09

GOCC:0005654

Nucleoplasm

4 of 302

1.35

1.03

0.0031

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0694

RNA-binding

6 of 130

1.9

3.3

1.45e-08

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000504

RNA recognition motif domain

6 of 70

2.16

3.89

5.37e-09

IPR035979

RNA-binding domain superfamily

6 of 81

2.1

3.78

6.19e-09

IPR012677

Nucleotide-binding alpha-beta plait domain superfamily

6 of 81

2.1

3.78

6.19e-09

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00360

RNA recognition motif

6 of 69

2.17

4.29

5.45e-10

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