SDO10557.1 protein (Filomicrobium insigne) - STRING interaction network

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

SDO10557.1

Ferric iron reductase protein FhuF. (260 aa)

Predicted Functional Partners:

SDO10587.1

0.795

SDO10526.1

0.778

SDO08200.1

0.748

SDO16826.1

0.748

SDO37868.1

0.748

SDO69783.1

0.748

SDP27123.1

0.692

SDP20216.1

0.644

SDO88541.1

0.485

SDO36365.1

0.471

Your Current Organism:

Filomicrobium insigne

NCBI taxonomy Id: 418854
Other names: CGMCC 1.6497, F. insigne, Filomicrobium insigne Wu et al. 2009, Hyphomicrobium sp. SLG5B-19, LMG 23927, LMG:23927, strain SLG5B-19

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SDO08200.1	SDO10557.1	SAMN04488061_0208	SAMN04488061_0275	Protein TonB.	Ferric iron reductase protein FhuF.	0.748
SDO08200.1	SDO10587.1	SAMN04488061_0208	SAMN04488061_0276	Protein TonB.	Iron complex outermembrane recepter protein.	0.833
SDO08200.1	SDO16826.1	SAMN04488061_0208	SAMN04488061_0466	Protein TonB.	Protein TonB.	0.417
SDO10526.1	SDO10557.1	SAMN04488061_0274	SAMN04488061_0275	Putative ATP-binding cassette transporter.	Ferric iron reductase protein FhuF.	0.778
SDO10526.1	SDO10587.1	SAMN04488061_0274	SAMN04488061_0276	Putative ATP-binding cassette transporter.	Iron complex outermembrane recepter protein.	0.597
SDO10557.1	SDO08200.1	SAMN04488061_0275	SAMN04488061_0208	Ferric iron reductase protein FhuF.	Protein TonB.	0.748
SDO10557.1	SDO10526.1	SAMN04488061_0275	SAMN04488061_0274	Ferric iron reductase protein FhuF.	Putative ATP-binding cassette transporter.	0.778
SDO10557.1	SDO10587.1	SAMN04488061_0275	SAMN04488061_0276	Ferric iron reductase protein FhuF.	Iron complex outermembrane recepter protein.	0.795
SDO10557.1	SDO16826.1	SAMN04488061_0275	SAMN04488061_0466	Ferric iron reductase protein FhuF.	Protein TonB.	0.748
SDO10557.1	SDO36365.1	SAMN04488061_0275	SAMN04488061_0998	Ferric iron reductase protein FhuF.	Aminoglycoside 6'-N-acetyltransferase.	0.471
SDO10557.1	SDO37868.1	SAMN04488061_0275	SAMN04488061_1035	Ferric iron reductase protein FhuF.	Protein TonB.	0.748
SDO10557.1	SDO69783.1	SAMN04488061_0275	SAMN04488061_1418	Ferric iron reductase protein FhuF.	Colicin import membrane protein.	0.748
SDO10557.1	SDO88541.1	SAMN04488061_0275	SAMN04488061_1915	Ferric iron reductase protein FhuF.	Methylamine dehydrogenase large subunit.	0.485
SDO10557.1	SDP20216.1	SAMN04488061_0275	SAMN04488061_2481	Ferric iron reductase protein FhuF.	Hypothetical protein.	0.644
SDO10557.1	SDP27123.1	SAMN04488061_0275	SAMN04488061_2681	Ferric iron reductase protein FhuF.	Paraquat-inducible protein A.	0.692
SDO10587.1	SDO08200.1	SAMN04488061_0276	SAMN04488061_0208	Iron complex outermembrane recepter protein.	Protein TonB.	0.833
SDO10587.1	SDO10526.1	SAMN04488061_0276	SAMN04488061_0274	Iron complex outermembrane recepter protein.	Putative ATP-binding cassette transporter.	0.597
SDO10587.1	SDO10557.1	SAMN04488061_0276	SAMN04488061_0275	Iron complex outermembrane recepter protein.	Ferric iron reductase protein FhuF.	0.795
SDO10587.1	SDO16826.1	SAMN04488061_0276	SAMN04488061_0466	Iron complex outermembrane recepter protein.	Protein TonB.	0.818
SDO10587.1	SDO37868.1	SAMN04488061_0276	SAMN04488061_1035	Iron complex outermembrane recepter protein.	Protein TonB.	0.815

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

20

average node degree:

3.64

avg. local clustering coefficient:

0.82

expected number of edges:

11

PPI enrichment p-value:

0.008

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006364

rRNA processing

7 of 266

1.63

2.41

3.60e-07

GO:0042254

Ribosome biogenesis

8 of 390

1.52

2.3

1.12e-07

GO:0042273

Ribosomal large subunit biogenesis

4 of 132

1.69

1.34

0.0014

GO:0000470

Maturation of LSU-rRNA

3 of 47

2.01

1.23

0.0043

GO:0007183

SMAD protein complex assembly

2 of 6

2.73

1.09

0.0106

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070412

R-SMAD binding

3 of 26

2.27

1.43

0.0021

GO:0030515

snoRNA binding

3 of 39

2.1

1.3

0.0033

GO:0070411

I-SMAD binding

2 of 15

2.33

0.87

0.0258

GO:0070410

co-SMAD binding

2 of 12

2.43

0.87

0.0258

GO:0034511

U3 snoRNA binding

2 of 12

2.43

0.87

0.0258

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005730

Nucleolus

7 of 827

1.14

1.09

0.00023

GO:0071144

Heteromeric SMAD protein complex

2 of 9

2.56

1.08

0.0107

GO:0030684

Preribosome

3 of 99

1.69

0.96

0.0114

GO:0030686

90S preribosome

2 of 35

1.97

0.77

0.0351

GO:0031981

Nuclear lumen

9 of 3371

0.64

0.44

0.0100

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:14660

Preribosome, and rRNA processing

7 of 181

1.8

3.09

1.60e-08

CL:14666

Preribosome, and Ribosome biogenesis

6 of 154

1.8

2.73

2.74e-07

CL:14845

Mixed, incl. Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), and Noc1p-Noc2p complex

3 of 10

2.69

2.39

3.88e-05

CL:14670

Small-subunit processome, and Positive regulation of rRNA processing

3 of 65

1.87

1.28

0.0028

CL:14772

Preribosome, small subunit precursor, and rRNA (adenine-N6,N6-)-dimethyltransferase activity

2 of 14

2.36

1.07

0.0108

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03008

Ribosome biogenesis in eukaryotes

3 of 127

1.58

0.82

0.0208

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2173788

Downregulation of TGF-beta receptor signaling

3 of 21

2.36

1.72

0.00060

MAP-2173789

TGF-beta receptor signaling activates SMADs

3 of 45

2.03

1.35

0.0025

MAP-1181150

Signaling by NODAL

2 of 12

2.43

0.96

0.0178

MAP-9617828

FOXO-mediated transcription of cell cycle genes

2 of 16

2.31

0.95

0.0180

MAP-1502540

Signaling by Activin

2 of 16

2.31

0.95

0.0180

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001946

Myofibroblast

2 of 5

2.81

1.02

0.0145

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0071142

Homomeric SMAD protein complex

2 of 5

2.81

1.02

0.0141

GOCC:0005730

Nucleolus

4 of 309

1.32

0.7

0.0271

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00524

Domain B in dwarfin family proteins

2 of 9

2.56

1.01

0.0147

SM00523

Domain A in dwarfin family proteins

2 of 13

2.4

1.0

0.0147

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