STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
groLChaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (542 aa)    
Predicted Functional Partners:
groS
Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.
 
 
 0.999
grpE
Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...]
 
 0.975
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
 
 
 0.974
KXB80838.1
Hsp90 protein; KEGG: eab:ECABU_c05560 3.7e-67 htpG; heat shock protein HtpG K04079; Psort location: Cytoplasmic, score: 9.97.
   
 
 0.946
KXB74114.1
KEGG: pdn:HMPREF9137_1408 1.2e-116 lipid kinase, YegS/Rv2252/BmrU family K07029; Psort location: Cytoplasmic, score: 9.26.
    
  0.942
KXB78030.1
Pyruvate synthase; KEGG: pdn:HMPREF9137_1524 0. nifJ; pyruvate synthase K03737; Psort location: Cytoplasmic, score: 8.96.
  
 
 0.885
KXB78156.1
Hypothetical protein; KEGG: apb:SAR116_1299 5.3e-107 endonuclease.
   
 0.877
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 0.824
KXB80119.1
Thioredoxin; KEGG: cla:Cla_1412 1.0e-25 trx; thioredoxin K03671; Psort location: Cytoplasmic, score: 9.26; Belongs to the thioredoxin family.
  
 
 0.794
KXB77318.1
KEGG: pmz:HMPREF0659_A5379 2.4e-166 fba; fructose-1,6-bisphosphate aldolase, class II K01624; Psort location: Cytoplasmic, score: 9.97.
   
 
 0.752
Your Current Organism:
Prevotella amnii
NCBI taxonomy Id: 419005
Other names: CCUG 53648, DSM 23384, JCM 14753, P. amnii, Prevotella amnii Lawson et al. 2008 emend. Hahnke et al. 2016
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