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KXB79946.1Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (161 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
 
 
 0.997
KXB78011.1
Protein FolC; KEGG: pmz:HMPREF0659_A7254 1.6e-155 folC; bifunctional protein FolC; K11754 dihydrofolate synthase / folylpolyglutamate synthase; Psort location: Cytoplasmic, score: 9.97.
     
 0.940
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.896
fhs
Formate--tetrahydrofolate ligase; KEGG: pmz:HMPREF0659_A6755 1.2e-228 fhs; formate--tetrahydrofolate ligase K01938; Psort location: Cytoplasmic, score: 8.96.
  
 
 0.873
KXB77330.1
AICARFT/IMPCHase bienzyme; KEGG: pmz:HMPREF0659_A5388 1.1e-188 AICARFT/IMPCHase bienzyme; K00602 phosphoribosylaminoimidazolecarboxamide formyltransferase.
    
 0.851
KXB78228.1
KEGG: pit:PIN17_A1822 3.4e-144 ftcD; glutamate formimidoyltransferase; Psort location: Cytoplasmic, score: 8.96.
     
 0.842
clpX
ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
   
 
 0.772
fmt
methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family.
    
 0.727
KXB79948.1
NOL1/NOP2/sun family protein; KEGG: lbh:Lbuc_1064 1.4e-44 RNA methylase; Psort location: Cytoplasmic, score: 9.26.
  
    0.709
KXB79765.1
KEGG: cba:CLB_2447 2.1e-16 Clp protease; K01358 ATP-dependent Clp protease, protease subunit; Psort location: Cytoplasmic, score: 8.96; Belongs to the peptidase S14 family.
    
 
 0.648
Your Current Organism:
Prevotella amnii
NCBI taxonomy Id: 419005
Other names: CCUG 53648, DSM 23384, JCM 14753, P. amnii, Prevotella amnii Lawson et al. 2008 emend. Hahnke et al. 2016
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