| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KXB74137.1 | nadE | HMPREF1860_02127 | HMPREF1860_00966 | Malic enzyme, NAD binding domain protein; KEGG: pmz:HMPREF0659_A6863 1.2e-187 malate dehydrogenase (oxaloacetate-decarboxylating) K00029; Psort location: Cytoplasmic, score: 9.97. | NAD+ synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.860 |
| KXB74137.1 | nadK | HMPREF1860_02127 | HMPREF1860_00519 | Malic enzyme, NAD binding domain protein; KEGG: pmz:HMPREF0659_A6863 1.2e-187 malate dehydrogenase (oxaloacetate-decarboxylating) K00029; Psort location: Cytoplasmic, score: 9.97. | NAD(+)/NADH kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.647 |
| KXB77494.1 | KXB80274.1 | HMPREF1860_01391 | HMPREF1860_00357 | Competence/damage-inducible protein CinA domain protein; KEGG: cco:CCC13826_0279 1.3e-17 fadD; long-chain-fatty-acid--CoA ligase K03743; Psort location: Cytoplasmic, score: 8.96; Belongs to the CinA family. | Putative NAD(+) diphosphatase; KEGG: pmz:HMPREF0659_A5588 5.2e-100 hydrolase, NUDIX family; K03426 NAD+ diphosphatase; Psort location: Cytoplasmic, score: 8.96. | 0.863 |
| KXB77494.1 | nadD | HMPREF1860_01391 | HMPREF1860_01369 | Competence/damage-inducible protein CinA domain protein; KEGG: cco:CCC13826_0279 1.3e-17 fadD; long-chain-fatty-acid--CoA ligase K03743; Psort location: Cytoplasmic, score: 8.96; Belongs to the CinA family. | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.940 |
| KXB77494.1 | nadE | HMPREF1860_01391 | HMPREF1860_00966 | Competence/damage-inducible protein CinA domain protein; KEGG: cco:CCC13826_0279 1.3e-17 fadD; long-chain-fatty-acid--CoA ligase K03743; Psort location: Cytoplasmic, score: 8.96; Belongs to the CinA family. | NAD+ synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.916 |
| KXB77494.1 | nadK | HMPREF1860_01391 | HMPREF1860_00519 | Competence/damage-inducible protein CinA domain protein; KEGG: cco:CCC13826_0279 1.3e-17 fadD; long-chain-fatty-acid--CoA ligase K03743; Psort location: Cytoplasmic, score: 8.96; Belongs to the CinA family. | NAD(+)/NADH kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.572 |
| KXB79917.1 | KXB79919.1 | HMPREF1860_00518 | HMPREF1860_00520 | ABC transporter, ATP-binding protein; KEGG: tnr:Thena_1393 6.7e-52 xenobiotic-transporting ATPase K11085; Psort location: CytoplasmicMembrane, score: 10.00. | DJ-1 family protein; KEGG: stj:SALIVA_1125 8.5e-29 thiJ; 4-methyl-5(Beta-hydroxyethyl)-thiazole monophosphate synthesis protein; Psort location: Cytoplasmic, score: 9.97. | 0.643 |
| KXB79917.1 | ispD | HMPREF1860_00518 | HMPREF1860_00521 | ABC transporter, ATP-binding protein; KEGG: tnr:Thena_1393 6.7e-52 xenobiotic-transporting ATPase K11085; Psort location: CytoplasmicMembrane, score: 10.00. | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). | 0.587 |
| KXB79917.1 | nadK | HMPREF1860_00518 | HMPREF1860_00519 | ABC transporter, ATP-binding protein; KEGG: tnr:Thena_1393 6.7e-52 xenobiotic-transporting ATPase K11085; Psort location: CytoplasmicMembrane, score: 10.00. | NAD(+)/NADH kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.719 |
| KXB79917.1 | recG | HMPREF1860_00518 | HMPREF1860_00522 | ABC transporter, ATP-binding protein; KEGG: tnr:Thena_1393 6.7e-52 xenobiotic-transporting ATPase K11085; Psort location: CytoplasmicMembrane, score: 10.00. | ATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. | 0.528 |
| KXB79919.1 | KXB79917.1 | HMPREF1860_00520 | HMPREF1860_00518 | DJ-1 family protein; KEGG: stj:SALIVA_1125 8.5e-29 thiJ; 4-methyl-5(Beta-hydroxyethyl)-thiazole monophosphate synthesis protein; Psort location: Cytoplasmic, score: 9.97. | ABC transporter, ATP-binding protein; KEGG: tnr:Thena_1393 6.7e-52 xenobiotic-transporting ATPase K11085; Psort location: CytoplasmicMembrane, score: 10.00. | 0.643 |
| KXB79919.1 | ispD | HMPREF1860_00520 | HMPREF1860_00521 | DJ-1 family protein; KEGG: stj:SALIVA_1125 8.5e-29 thiJ; 4-methyl-5(Beta-hydroxyethyl)-thiazole monophosphate synthesis protein; Psort location: Cytoplasmic, score: 9.97. | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). | 0.820 |
| KXB79919.1 | nadE | HMPREF1860_00520 | HMPREF1860_00966 | DJ-1 family protein; KEGG: stj:SALIVA_1125 8.5e-29 thiJ; 4-methyl-5(Beta-hydroxyethyl)-thiazole monophosphate synthesis protein; Psort location: Cytoplasmic, score: 9.97. | NAD+ synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.624 |
| KXB79919.1 | nadK | HMPREF1860_00520 | HMPREF1860_00519 | DJ-1 family protein; KEGG: stj:SALIVA_1125 8.5e-29 thiJ; 4-methyl-5(Beta-hydroxyethyl)-thiazole monophosphate synthesis protein; Psort location: Cytoplasmic, score: 9.97. | NAD(+)/NADH kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.649 |
| KXB79919.1 | recG | HMPREF1860_00520 | HMPREF1860_00522 | DJ-1 family protein; KEGG: stj:SALIVA_1125 8.5e-29 thiJ; 4-methyl-5(Beta-hydroxyethyl)-thiazole monophosphate synthesis protein; Psort location: Cytoplasmic, score: 9.97. | ATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. | 0.700 |
| KXB80274.1 | KXB77494.1 | HMPREF1860_00357 | HMPREF1860_01391 | Putative NAD(+) diphosphatase; KEGG: pmz:HMPREF0659_A5588 5.2e-100 hydrolase, NUDIX family; K03426 NAD+ diphosphatase; Psort location: Cytoplasmic, score: 8.96. | Competence/damage-inducible protein CinA domain protein; KEGG: cco:CCC13826_0279 1.3e-17 fadD; long-chain-fatty-acid--CoA ligase K03743; Psort location: Cytoplasmic, score: 8.96; Belongs to the CinA family. | 0.863 |
| KXB80274.1 | nadD | HMPREF1860_00357 | HMPREF1860_01369 | Putative NAD(+) diphosphatase; KEGG: pmz:HMPREF0659_A5588 5.2e-100 hydrolase, NUDIX family; K03426 NAD+ diphosphatase; Psort location: Cytoplasmic, score: 8.96. | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.844 |
| KXB80274.1 | nadE | HMPREF1860_00357 | HMPREF1860_00966 | Putative NAD(+) diphosphatase; KEGG: pmz:HMPREF0659_A5588 5.2e-100 hydrolase, NUDIX family; K03426 NAD+ diphosphatase; Psort location: Cytoplasmic, score: 8.96. | NAD+ synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.846 |
| KXB80274.1 | nadK | HMPREF1860_00357 | HMPREF1860_00519 | Putative NAD(+) diphosphatase; KEGG: pmz:HMPREF0659_A5588 5.2e-100 hydrolase, NUDIX family; K03426 NAD+ diphosphatase; Psort location: Cytoplasmic, score: 8.96. | NAD(+)/NADH kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.841 |
| dxs | ispD | HMPREF1860_00927 | HMPREF1860_00521 | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). | 0.533 |