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query proteins and first shell of interactors
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glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (426 aa)    
Predicted Functional Partners:
fhs
Formate--tetrahydrofolate ligase; KEGG: pmz:HMPREF0659_A6755 1.2e-228 fhs; formate--tetrahydrofolate ligase K01938; Psort location: Cytoplasmic, score: 8.96.
  
 0.968
purL
Putative phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
  
 
 0.964
folD
Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
  
 0.956
KXB77330.1
AICARFT/IMPCHase bienzyme; KEGG: pmz:HMPREF0659_A5388 1.1e-188 AICARFT/IMPCHase bienzyme; K00602 phosphoribosylaminoimidazolecarboxamide formyltransferase.
  
 0.954
KXB79499.1
Ribose-5-phosphate isomerase B; KEGG: pdn:HMPREF9137_1889 2.0e-68 putative ribose-5-phosphate isomerase B; K01808 ribose 5-phosphate isomerase B; Psort location: Cytoplasmic, score: 8.96.
 
 
 0.948
KXB81957.1
KEGG: pdn:HMPREF9137_1128 1.3e-169 L-serine ammonia-lyase K01752; Psort location: Cytoplasmic, score: 9.26.
  
 
 0.934
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.898
KXB79946.1
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
  
 
 0.896
kbl
Glycine C-acetyltransferase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
  
 
 0.864
KXB80837.1
Xaa-His dipeptidase; KEGG: pdn:HMPREF9137_0071 3.8e-200 pepD_1; Xaa-His dipeptidase; Psort location: Cytoplasmic, score: 8.96.
   
 
 0.861
Your Current Organism:
Prevotella amnii
NCBI taxonomy Id: 419005
Other names: CCUG 53648, DSM 23384, JCM 14753, P. amnii, Prevotella amnii Lawson et al. 2008 emend. Hahnke et al. 2016
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