Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
KXB79097.1Hypothetical protein; KEGG: pmz:HMPREF0659_A6730 2.4e-182 hypothetical protein; K01933 phosphoribosylformylglycinamidine cyclo-ligase; Psort location: Cytoplasmic, score: 9.97. (382 aa)    
Predicted Functional Partners:
purL
Putative phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
 
 
 0.999
purC
KEGG: pmz:HMPREF0659_A6716 1.9e-150 purC; phosphoribosylaminoimidazolesuccinocarboxamide synthase K01923; Psort location: Cytoplasmic, score: 8.96; Belongs to the SAICAR synthetase family.
 
 0.998
KXB81937.1
KEGG: pmz:HMPREF0659_A5881 9.8e-273 class II glutamine amidotransferase; K00764 amidophosphoribosyltransferase; Psort location: Cytoplasmic, score: 8.96.
 
 
 0.988
KXB77050.1
Adenylosuccinate lyase; KEGG: pdn:HMPREF9137_0243 1.2e-203 purB; adenylosuccinate lyase K01756; Psort location: Cytoplasmic, score: 9.97.
 
 
 0.985
purD
KEGG: pmz:HMPREF0659_A6752 2.4e-175 purD; phosphoribosylamine--glycine ligase K01945; Psort location: Cytoplasmic, score: 9.97; Belongs to the GARS family.
 
 
 0.977
purE
Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
 
 
 0.959
purT
Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family.
  
 
 0.888
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
  
 0.853
thiC
Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
     
 0.844
KXB78135.1
MGS-like domain protein; KEGG: pdn:HMPREF9137_2093 6.7e-84 MGS-like domain-containing protein; K00602 phosphoribosylaminoimidazolecarboxamide formyltransferase.
 
  
 0.833
Your Current Organism:
Prevotella amnii
NCBI taxonomy Id: 419005
Other names: CCUG 53648, DSM 23384, JCM 14753, P. amnii, Prevotella amnii Lawson et al. 2008 emend. Hahnke et al. 2016
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