Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
sucDsuccinate-CoA ligase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (289 aa)    
Predicted Functional Partners:
sucC
succinate-CoA ligase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 0.999
KXB81737.1
KEGG: pdn:HMPREF9137_0601 6.3e-120 succinate dehydrogenase/fumarate reductase iron-sulfur subunit K00240; Psort location: Cytoplasmic, score: 8.96.
  
 0.985
KXB78018.1
Respiratory-chain NADH dehydrogenase, subunit; KEGG: pdn:HMPREF9137_1116 8.1e-246 hypothetical protein; K13378 NADH-quinone oxidoreductase subunit C/D; Psort location: Cytoplasmic, score: 9.12.
  
 
 0.982
KXB81736.1
KEGG: pdn:HMPREF9137_0600 0. sdhA; succinate dehydrogenase flavoprotein subunit K00239; Psort location: CytoplasmicMembrane, score: 7.88.
  
 0.975
KXB78030.1
Pyruvate synthase; KEGG: pdn:HMPREF9137_1524 0. nifJ; pyruvate synthase K03737; Psort location: Cytoplasmic, score: 8.96.
  
 0.972
KXB76224.1
Fumarate hydratase class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
  
 
 0.917
KXB77772.1
KEGG: pdn:HMPREF9137_0543 0. 2-oxoacid:acceptor oxidoreductase subunit alpha; K00174 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Psort location: Cytoplasmic, score: 8.96.
    
 0.905
KXB79160.1
KEGG: pmz:HMPREF0659_A5967 7.2e-32 4Fe-4S binding domain protein; K00176 2-oxoglutarate ferredoxin oxidoreductase subunit delta.
  
 0.878
atpH
ATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
  
 
 0.871
KXB81735.1
Succinate dehydrogenase cytochrome B subunit, b558 family; KEGG: bhl:Bache_0807 7.0e-73 succinate dehydrogenase subunit C K00241; Psort location: CytoplasmicMembrane, score: 10.00.
    
 0.863
Your Current Organism:
Prevotella amnii
NCBI taxonomy Id: 419005
Other names: CCUG 53648, DSM 23384, JCM 14753, P. amnii, Prevotella amnii Lawson et al. 2008 emend. Hahnke et al. 2016
Server load: low (22%) [HD]