STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dnaJChaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (382 aa)    
Predicted Functional Partners:
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
 0.999
grpE
Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...]
 
 
 0.990
KXB80838.1
Hsp90 protein; KEGG: eab:ECABU_c05560 3.7e-67 htpG; heat shock protein HtpG K04079; Psort location: Cytoplasmic, score: 9.97.
  
 0.978
KXB78030.1
Pyruvate synthase; KEGG: pdn:HMPREF9137_1524 0. nifJ; pyruvate synthase K03737; Psort location: Cytoplasmic, score: 8.96.
   
 
 0.911
KXB78292.1
Tetratricopeptide repeat protein; KEGG: apb:SAR116_1534 1.5e-05 hypothetical protein; Psort location: Cytoplasmic, score: 8.96.
   
 0.849
KXB81943.1
Tetratricopeptide repeat domain protein; KEGG: ccm:Ccan_18230 2.0e-91 PIF1/RRM3 DNA helicase-like protein; Psort location: Cytoplasmic, score: 8.96.
   
 0.811
KXB79105.1
Peptidase family M49; KEGG: pmz:HMPREF0659_A6864 7.1e-238 peptidase, M49 family; K01277 dipeptidyl-peptidase III; Psort location: Cytoplasmic, score: 8.96.
    
 0.787
rpsE
Ribosomal protein S5; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family.
  
 
 0.770
KXB78068.1
KEGG: pfe:PSF113_2023 1.0e-09 MerR family transcriptional regulator.
  
 
 0.766
KXB78011.1
Protein FolC; KEGG: pmz:HMPREF0659_A7254 1.6e-155 folC; bifunctional protein FolC; K11754 dihydrofolate synthase / folylpolyglutamate synthase; Psort location: Cytoplasmic, score: 9.97.
 
   
 0.761
Your Current Organism:
Prevotella amnii
NCBI taxonomy Id: 419005
Other names: CCUG 53648, DSM 23384, JCM 14753, P. amnii, Prevotella amnii Lawson et al. 2008 emend. Hahnke et al. 2016
Server load: medium (44%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.