Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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Score
fhsFormate--tetrahydrofolate ligase; KEGG: pmz:HMPREF0659_A6755 1.2e-228 fhs; formate--tetrahydrofolate ligase K01938; Psort location: Cytoplasmic, score: 8.96. (555 aa)    
Predicted Functional Partners:
folD
Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
 
 0.997
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.968
KXB77330.1
AICARFT/IMPCHase bienzyme; KEGG: pmz:HMPREF0659_A5388 1.1e-188 AICARFT/IMPCHase bienzyme; K00602 phosphoribosylaminoimidazolecarboxamide formyltransferase.
  
 0.944
KXB78228.1
KEGG: pit:PIN17_A1822 3.4e-144 ftcD; glutamate formimidoyltransferase; Psort location: Cytoplasmic, score: 8.96.
    
 0.919
purL
Putative phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
  
 
 0.903
fmt
methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family.
    
 0.893
KXB79946.1
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
  
 
 0.873
KXB78135.1
MGS-like domain protein; KEGG: pdn:HMPREF9137_2093 6.7e-84 MGS-like domain-containing protein; K00602 phosphoribosylaminoimidazolecarboxamide formyltransferase.
  
 0.823
purC
KEGG: pmz:HMPREF0659_A6716 1.9e-150 purC; phosphoribosylaminoimidazolesuccinocarboxamide synthase K01923; Psort location: Cytoplasmic, score: 8.96; Belongs to the SAICAR synthetase family.
  
 
 0.771
purD
KEGG: pmz:HMPREF0659_A6752 2.4e-175 purD; phosphoribosylamine--glycine ligase K01945; Psort location: Cytoplasmic, score: 9.97; Belongs to the GARS family.
  
 0.723
Your Current Organism:
Prevotella amnii
NCBI taxonomy Id: 419005
Other names: CCUG 53648, DSM 23384, JCM 14753, P. amnii, Prevotella amnii Lawson et al. 2008 emend. Hahnke et al. 2016
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