STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
purAAdenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (424 aa)    
Predicted Functional Partners:
KXB77050.1
Adenylosuccinate lyase; KEGG: pdn:HMPREF9137_0243 1.2e-203 purB; adenylosuccinate lyase K01756; Psort location: Cytoplasmic, score: 9.97.
 
 0.984
purL
Putative phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
  
  
 0.964
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
 
 
 0.951
guaA
GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP.
 
  
 0.890
KXB77330.1
AICARFT/IMPCHase bienzyme; KEGG: pmz:HMPREF0659_A5388 1.1e-188 AICARFT/IMPCHase bienzyme; K00602 phosphoribosylaminoimidazolecarboxamide formyltransferase.
  
 0.872
KXB80412.1
Kinase, PfkB family; KEGG: pmz:HMPREF0659_A5106 2.0e-116 kinase, PfkB family; K00847 fructokinase; Psort location: Cytoplasmic, score: 8.96.
  
 0.851
KXB77644.1
Transcriptional regulator, Fur family; KEGG: mct:MCR_0333 5.0e-08 fur; ferric uptake regulation protein Fur K03711; Psort location: Cytoplasmic, score: 8.96; Belongs to the Fur family.
       0.849
purC
KEGG: pmz:HMPREF0659_A6716 1.9e-150 purC; phosphoribosylaminoimidazolesuccinocarboxamide synthase K01923; Psort location: Cytoplasmic, score: 8.96; Belongs to the SAICAR synthetase family.
  
 0.802
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
  
 0.772
KXB78135.1
MGS-like domain protein; KEGG: pdn:HMPREF9137_2093 6.7e-84 MGS-like domain-containing protein; K00602 phosphoribosylaminoimidazolecarboxamide formyltransferase.
  
 0.768
Your Current Organism:
Prevotella amnii
NCBI taxonomy Id: 419005
Other names: CCUG 53648, DSM 23384, JCM 14753, P. amnii, Prevotella amnii Lawson et al. 2008 emend. Hahnke et al. 2016
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