| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KXB74208.1 | msrA | HMPREF1860_02199 | HMPREF1860_01476 | Cytochrome C biogenesis protein transmembrane region; KEGG: bsa:Bacsa_2272 1.0e-213 Protein-disulfide reductase; Psort location: CytoplasmicMembrane, score: 10.00. | methionine-R-sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | 0.969 |
| KXB77307.1 | KXB79113.1 | HMPREF1860_01477 | HMPREF1860_00657 | Thioredoxin-disulfide reductase; KEGG: pmz:HMPREF0659_A6627 2.7e-135 trxB; thioredoxin-disulfide reductase K00384; Psort location: Cytoplasmic, score: 9.97. | Glutathione peroxidase; KEGG: pdn:HMPREF9137_0089 1.6e-82 peroxiredoxin HYR1 K00432; Psort location: Cytoplasmic, score: 9.97; Belongs to the glutathione peroxidase family. | 0.411 |
| KXB77307.1 | guaB | HMPREF1860_01477 | HMPREF1860_01772 | Thioredoxin-disulfide reductase; KEGG: pmz:HMPREF0659_A6627 2.7e-135 trxB; thioredoxin-disulfide reductase K00384; Psort location: Cytoplasmic, score: 9.97. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.583 |
| KXB77307.1 | msrA | HMPREF1860_01477 | HMPREF1860_01476 | Thioredoxin-disulfide reductase; KEGG: pmz:HMPREF0659_A6627 2.7e-135 trxB; thioredoxin-disulfide reductase K00384; Psort location: Cytoplasmic, score: 9.97. | methionine-R-sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | 0.898 |
| KXB78442.1 | KXB79113.1 | HMPREF1860_00944 | HMPREF1860_00657 | Glutathione peroxidase; KEGG: pmz:HMPREF0659_A5940 2.2e-69 glutathione peroxidase K00432; Psort location: Cytoplasmic, score: 9.97. | Glutathione peroxidase; KEGG: pdn:HMPREF9137_0089 1.6e-82 peroxiredoxin HYR1 K00432; Psort location: Cytoplasmic, score: 9.97; Belongs to the glutathione peroxidase family. | 0.841 |
| KXB78442.1 | msrA | HMPREF1860_00944 | HMPREF1860_01476 | Glutathione peroxidase; KEGG: pmz:HMPREF0659_A5940 2.2e-69 glutathione peroxidase K00432; Psort location: Cytoplasmic, score: 9.97. | methionine-R-sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | 0.780 |
| KXB79113.1 | KXB77307.1 | HMPREF1860_00657 | HMPREF1860_01477 | Glutathione peroxidase; KEGG: pdn:HMPREF9137_0089 1.6e-82 peroxiredoxin HYR1 K00432; Psort location: Cytoplasmic, score: 9.97; Belongs to the glutathione peroxidase family. | Thioredoxin-disulfide reductase; KEGG: pmz:HMPREF0659_A6627 2.7e-135 trxB; thioredoxin-disulfide reductase K00384; Psort location: Cytoplasmic, score: 9.97. | 0.411 |
| KXB79113.1 | KXB78442.1 | HMPREF1860_00657 | HMPREF1860_00944 | Glutathione peroxidase; KEGG: pdn:HMPREF9137_0089 1.6e-82 peroxiredoxin HYR1 K00432; Psort location: Cytoplasmic, score: 9.97; Belongs to the glutathione peroxidase family. | Glutathione peroxidase; KEGG: pmz:HMPREF0659_A5940 2.2e-69 glutathione peroxidase K00432; Psort location: Cytoplasmic, score: 9.97. | 0.841 |
| KXB79113.1 | msrA | HMPREF1860_00657 | HMPREF1860_01476 | Glutathione peroxidase; KEGG: pdn:HMPREF9137_0089 1.6e-82 peroxiredoxin HYR1 K00432; Psort location: Cytoplasmic, score: 9.97; Belongs to the glutathione peroxidase family. | methionine-R-sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | 0.780 |
| clpX | grpE | HMPREF1860_01836 | HMPREF1860_01055 | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.465 |
| clpX | guaB | HMPREF1860_01836 | HMPREF1860_01772 | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.526 |
| clpX | msrA | HMPREF1860_01836 | HMPREF1860_01476 | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | methionine-R-sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | 0.799 |
| grpE | clpX | HMPREF1860_01055 | HMPREF1860_01836 | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.465 |
| grpE | msrA | HMPREF1860_01055 | HMPREF1860_01476 | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | methionine-R-sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | 0.810 |
| grpE | polA | HMPREF1860_01055 | HMPREF1860_00085 | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.525 |
| guaB | KXB77307.1 | HMPREF1860_01772 | HMPREF1860_01477 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Thioredoxin-disulfide reductase; KEGG: pmz:HMPREF0659_A6627 2.7e-135 trxB; thioredoxin-disulfide reductase K00384; Psort location: Cytoplasmic, score: 9.97. | 0.583 |
| guaB | clpX | HMPREF1860_01772 | HMPREF1860_01836 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.526 |
| guaB | msrA | HMPREF1860_01772 | HMPREF1860_01476 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | methionine-R-sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | 0.744 |
| guaB | polA | HMPREF1860_01772 | HMPREF1860_00085 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.460 |
| guaB | rpmJ | HMPREF1860_01772 | HMPREF1860_00210 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family. | 0.439 |
