STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KXB76224.1Fumarate hydratase class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (546 aa)    
Predicted Functional Partners:
KXB81736.1
KEGG: pdn:HMPREF9137_0600 0. sdhA; succinate dehydrogenase flavoprotein subunit K00239; Psort location: CytoplasmicMembrane, score: 7.88.
  
 
 0.995
KXB77455.1
KEGG: pdn:HMPREF9137_0880 1.7e-149 lactate/malate dehydrogenase, NAD binding domain-containing protein; K00024 malate dehydrogenase; Psort location: Cytoplasmic, score: 9.26; Belongs to the LDH/MDH superfamily.
  
 
 0.995
KXB81737.1
KEGG: pdn:HMPREF9137_0601 6.3e-120 succinate dehydrogenase/fumarate reductase iron-sulfur subunit K00240; Psort location: Cytoplasmic, score: 8.96.
  
 
 0.984
KXB74137.1
Malic enzyme, NAD binding domain protein; KEGG: pmz:HMPREF0659_A6863 1.2e-187 malate dehydrogenase (oxaloacetate-decarboxylating) K00029; Psort location: Cytoplasmic, score: 9.97.
 
 
 0.976
KXB81735.1
Succinate dehydrogenase cytochrome B subunit, b558 family; KEGG: bhl:Bache_0807 7.0e-73 succinate dehydrogenase subunit C K00241; Psort location: CytoplasmicMembrane, score: 10.00.
    
 0.901
KXB79913.1
FAH family protein; KEGG: rsi:Runsl_3652 2.0e-52 5-carboxymethyl-2-hydroxymuconate Delta-isomerase; Psort location: Cytoplasmic, score: 9.97.
    
  0.887
KXB78030.1
Pyruvate synthase; KEGG: pdn:HMPREF9137_1524 0. nifJ; pyruvate synthase K03737; Psort location: Cytoplasmic, score: 8.96.
    
 0.868
pckA
Phosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
   
 
 0.854
sucC
succinate-CoA ligase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 
 0.852
sucD
succinate-CoA ligase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 
 0.820
Your Current Organism:
Prevotella amnii
NCBI taxonomy Id: 419005
Other names: CCUG 53648, DSM 23384, JCM 14753, P. amnii, Prevotella amnii Lawson et al. 2008 emend. Hahnke et al. 2016
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