STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KXB75062.1KEGG: pit:PIN17_A0611 1.1e-76 thiD; phosphomethylpyrimidine kinase K00941; Psort location: Cytoplasmic, score: 8.96. (271 aa)    
Predicted Functional Partners:
thiE
Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
 0.999
thiC
Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
  
 
 0.988
KXB75066.1
Thiamine monophosphate synthase/TENI; KEGG: pit:PIN17_A0607 8.0e-49 putative thiamine-phosphate diphosphorylase; K00788 thiamine-phosphate pyrophosphorylase.
 
 
 0.961
KXB74489.1
KEGG: bhl:Bache_2367 8.7e-36 phosphomethylpyrimidine kinase K00941; Psort location: Cytoplasmic, score: 9.26.
  
  
 
0.828
thi4
Thiazole biosynthesis enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
  
  
 0.740
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
   
 
 0.687
KXB78968.1
Putative pyridoxal kinase; KEGG: pmz:HMPREF0659_A6314 7.6e-115 phosphomethylpyrimidine kinase K00868; Psort location: Cytoplasmic, score: 8.96.
   
 
 0.675
KXB81586.1
Hypothetical protein; KEGG: cby:CLM_0574 0.00014 bacteriocin biosynthesis cyclodehydratase; Psort location: Cytoplasmic, score: 8.96.
 
  
 0.496
KXB77437.1
KEGG: pdn:HMPREF9137_0656 1.9e-262 putative cold-shock DEAD-box protein A; K05592 ATP-dependent RNA helicase DeaD; Psort location: Cytoplasmic, score: 9.97.
 
 
    0.477
KXB79964.1
KEGG: pmz:HMPREF0659_A6426 7.5e-69 thiamine diphosphokinase K00949.
    
 0.459
Your Current Organism:
Prevotella amnii
NCBI taxonomy Id: 419005
Other names: CCUG 53648, DSM 23384, JCM 14753, P. amnii, Prevotella amnii Lawson et al. 2008 emend. Hahnke et al. 2016
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