STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gyrBDNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (656 aa)    
Predicted Functional Partners:
gyrA
DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
 
 0.976
KXB76235.1
KEGG: pmz:HMPREF0659_A6144 0. DNA gyrase/topoisomerase IV, A subunit; K02621 topoisomerase IV subunit A; Psort location: Cytoplasmic, score: 9.97.
 
 
 0.913
KXB77397.1
Hypothetical protein; KEGG: efc:EFAU004_01897 0.00078 IS1380 family transposase; Psort location: Cytoplasmic, score: 8.96.
  
 
 0.824
KXB76963.1
Hypothetical protein; Psort location: Cytoplasmic, score: 8.96.
  
 
 0.824
KXB75442.1
Transposase, IS4 family; KEGG: efc:EFAU004_01897 0.0036 IS1380 family transposase; Psort location: Cytoplasmic, score: 8.96.
  
 
 0.824
KXB75028.1
Hypothetical protein; Psort location: Cytoplasmic, score: 8.96.
  
 
 0.824
KXB74966.1
Hypothetical protein; Psort location: CytoplasmicMembrane, score: 9.82.
  
 
 0.824
rpsT
Ribosomal protein S20; Binds directly to 16S ribosomal RNA.
     
 0.675
recO
DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination.
  
  
 0.612
rpoB
DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
  
 0.598
Your Current Organism:
Prevotella amnii
NCBI taxonomy Id: 419005
Other names: CCUG 53648, DSM 23384, JCM 14753, P. amnii, Prevotella amnii Lawson et al. 2008 emend. Hahnke et al. 2016
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