| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KXB74143.1 | glyA | HMPREF1860_02133 | HMPREF1860_00619 | Haloacid dehalogenase-like hydrolase; KEGG: zga:zobellia_482 1.1e-42 nanP; N-acylneuraminate-9-phosphatase K07025; Psort location: Cytoplasmic, score: 8.96. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.532 |
| KXB74143.1 | trpF | HMPREF1860_02133 | HMPREF1860_02193 | Haloacid dehalogenase-like hydrolase; KEGG: zga:zobellia_482 1.1e-42 nanP; N-acylneuraminate-9-phosphatase K07025; Psort location: Cytoplasmic, score: 8.96. | KEGG: pmz:HMPREF0659_A5926 6.9e-50 putative N-(5'phosphoribosyl)anthranilate isomerase; K01817 phosphoribosylanthranilate isomerase; Psort location: Cytoplasmic, score: 8.96; Belongs to the TrpF family. | 0.452 |
| KXB74200.1 | KXB74201.1 | HMPREF1860_02191 | HMPREF1860_02192 | KEGG: pdn:HMPREF9137_1184 5.8e-85 rpe; ribulose-phosphate 3-epimerase K01783; Psort location: Cytoplasmic, score: 9.26. | KEGG: pru:PRU_1458 1.7e-62 trpC; indole-3-glycerol phosphate synthase K01609; Psort location: Cytoplasmic, score: 9.97. | 0.559 |
| KXB74200.1 | KXB74203.1 | HMPREF1860_02191 | HMPREF1860_02194 | KEGG: pdn:HMPREF9137_1184 5.8e-85 rpe; ribulose-phosphate 3-epimerase K01783; Psort location: Cytoplasmic, score: 9.26. | Transcription termination/antitermination factor NusG. | 0.413 |
| KXB74200.1 | trpF | HMPREF1860_02191 | HMPREF1860_02193 | KEGG: pdn:HMPREF9137_1184 5.8e-85 rpe; ribulose-phosphate 3-epimerase K01783; Psort location: Cytoplasmic, score: 9.26. | KEGG: pmz:HMPREF0659_A5926 6.9e-50 putative N-(5'phosphoribosyl)anthranilate isomerase; K01817 phosphoribosylanthranilate isomerase; Psort location: Cytoplasmic, score: 8.96; Belongs to the TrpF family. | 0.578 |
| KXB74201.1 | KXB74200.1 | HMPREF1860_02192 | HMPREF1860_02191 | KEGG: pru:PRU_1458 1.7e-62 trpC; indole-3-glycerol phosphate synthase K01609; Psort location: Cytoplasmic, score: 9.97. | KEGG: pdn:HMPREF9137_1184 5.8e-85 rpe; ribulose-phosphate 3-epimerase K01783; Psort location: Cytoplasmic, score: 9.26. | 0.559 |
| KXB74201.1 | KXB74203.1 | HMPREF1860_02192 | HMPREF1860_02194 | KEGG: pru:PRU_1458 1.7e-62 trpC; indole-3-glycerol phosphate synthase K01609; Psort location: Cytoplasmic, score: 9.97. | Transcription termination/antitermination factor NusG. | 0.585 |
| KXB74201.1 | KXB75994.1 | HMPREF1860_02192 | HMPREF1860_01663 | KEGG: pru:PRU_1458 1.7e-62 trpC; indole-3-glycerol phosphate synthase K01609; Psort location: Cytoplasmic, score: 9.97. | KEGG: osp:Odosp_0584 6.7e-84 Aminodeoxychorismate synthase K01665; Psort location: Cytoplasmic, score: 9.97. | 0.994 |
| KXB74201.1 | KXB75995.1 | HMPREF1860_02192 | HMPREF1860_01664 | KEGG: pru:PRU_1458 1.7e-62 trpC; indole-3-glycerol phosphate synthase K01609; Psort location: Cytoplasmic, score: 9.97. | KEGG: pit:PIN17_A1708 2.1e-41 glutamine amidotransferase; K01658 anthranilate synthase component II; Psort location: Cytoplasmic, score: 9.26. | 0.999 |
| KXB74201.1 | KXB79166.1 | HMPREF1860_02192 | HMPREF1860_00710 | KEGG: pru:PRU_1458 1.7e-62 trpC; indole-3-glycerol phosphate synthase K01609; Psort location: Cytoplasmic, score: 9.97. | KEGG: pdn:HMPREF9137_1471 1.2e-157 putative 3-deoxy-7-phosphoheptulonate synthase; K04516 chorismate mutase; Psort location: Cytoplasmic, score: 9.97. | 0.712 |
| KXB74201.1 | aroC | HMPREF1860_02192 | HMPREF1860_00258 | KEGG: pru:PRU_1458 1.7e-62 trpC; indole-3-glycerol phosphate synthase K01609; Psort location: Cytoplasmic, score: 9.97. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.674 |
| KXB74201.1 | glyA | HMPREF1860_02192 | HMPREF1860_00619 | KEGG: pru:PRU_1458 1.7e-62 trpC; indole-3-glycerol phosphate synthase K01609; Psort location: Cytoplasmic, score: 9.97. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.456 |
| KXB74201.1 | trpF | HMPREF1860_02192 | HMPREF1860_02193 | KEGG: pru:PRU_1458 1.7e-62 trpC; indole-3-glycerol phosphate synthase K01609; Psort location: Cytoplasmic, score: 9.97. | KEGG: pmz:HMPREF0659_A5926 6.9e-50 putative N-(5'phosphoribosyl)anthranilate isomerase; K01817 phosphoribosylanthranilate isomerase; Psort location: Cytoplasmic, score: 8.96; Belongs to the TrpF family. | 0.999 |
| KXB74203.1 | KXB74200.1 | HMPREF1860_02194 | HMPREF1860_02191 | Transcription termination/antitermination factor NusG. | KEGG: pdn:HMPREF9137_1184 5.8e-85 rpe; ribulose-phosphate 3-epimerase K01783; Psort location: Cytoplasmic, score: 9.26. | 0.413 |
| KXB74203.1 | KXB74201.1 | HMPREF1860_02194 | HMPREF1860_02192 | Transcription termination/antitermination factor NusG. | KEGG: pru:PRU_1458 1.7e-62 trpC; indole-3-glycerol phosphate synthase K01609; Psort location: Cytoplasmic, score: 9.97. | 0.585 |
| KXB74203.1 | trpF | HMPREF1860_02194 | HMPREF1860_02193 | Transcription termination/antitermination factor NusG. | KEGG: pmz:HMPREF0659_A5926 6.9e-50 putative N-(5'phosphoribosyl)anthranilate isomerase; K01817 phosphoribosylanthranilate isomerase; Psort location: Cytoplasmic, score: 8.96; Belongs to the TrpF family. | 0.631 |
| KXB75994.1 | KXB74201.1 | HMPREF1860_01663 | HMPREF1860_02192 | KEGG: osp:Odosp_0584 6.7e-84 Aminodeoxychorismate synthase K01665; Psort location: Cytoplasmic, score: 9.97. | KEGG: pru:PRU_1458 1.7e-62 trpC; indole-3-glycerol phosphate synthase K01609; Psort location: Cytoplasmic, score: 9.97. | 0.994 |
| KXB75994.1 | KXB75995.1 | HMPREF1860_01663 | HMPREF1860_01664 | KEGG: osp:Odosp_0584 6.7e-84 Aminodeoxychorismate synthase K01665; Psort location: Cytoplasmic, score: 9.97. | KEGG: pit:PIN17_A1708 2.1e-41 glutamine amidotransferase; K01658 anthranilate synthase component II; Psort location: Cytoplasmic, score: 9.26. | 0.999 |
| KXB75994.1 | KXB79166.1 | HMPREF1860_01663 | HMPREF1860_00710 | KEGG: osp:Odosp_0584 6.7e-84 Aminodeoxychorismate synthase K01665; Psort location: Cytoplasmic, score: 9.97. | KEGG: pdn:HMPREF9137_1471 1.2e-157 putative 3-deoxy-7-phosphoheptulonate synthase; K04516 chorismate mutase; Psort location: Cytoplasmic, score: 9.97. | 0.933 |
| KXB75994.1 | aroC | HMPREF1860_01663 | HMPREF1860_00258 | KEGG: osp:Odosp_0584 6.7e-84 Aminodeoxychorismate synthase K01665; Psort location: Cytoplasmic, score: 9.97. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.934 |