node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDO07225.1 | SDO08965.1 | SAMN04487957_103233 | SAMN04487957_103293 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | O-acetylhomoserine (thiol)-lyase. | 0.984 |
SDO07225.1 | SDO49007.1 | SAMN04487957_103233 | SAMN04487957_10714 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | 0.999 |
SDO07225.1 | SDO75824.1 | SAMN04487957_103233 | SAMN04487957_11143 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | D-methionine transport system substrate-binding protein. | 0.473 |
SDO07225.1 | cysC | SAMN04487957_103233 | SAMN04487957_1097 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Bifunctional enzyme CysN/CysC; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. | 0.544 |
SDO07225.1 | metE | SAMN04487957_103233 | SAMN04487957_10123 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methionine synthase (B12-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.986 |
SDO07225.1 | metG | SAMN04487957_103233 | SAMN04487957_11610 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.957 |
SDO07225.1 | metK | SAMN04487957_103233 | SAMN04487957_10718 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.983 |
SDO07225.1 | metN | SAMN04487957_103233 | SAMN04487957_11145 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | D-methionine transport system ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. | 0.870 |
SDO08965.1 | SDO07225.1 | SAMN04487957_103293 | SAMN04487957_103233 | O-acetylhomoserine (thiol)-lyase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.984 |
SDO08965.1 | SDO49007.1 | SAMN04487957_103293 | SAMN04487957_10714 | O-acetylhomoserine (thiol)-lyase. | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | 0.531 |
SDO08965.1 | SDO75824.1 | SAMN04487957_103293 | SAMN04487957_11143 | O-acetylhomoserine (thiol)-lyase. | D-methionine transport system substrate-binding protein. | 0.691 |
SDO08965.1 | cysC | SAMN04487957_103293 | SAMN04487957_1097 | O-acetylhomoserine (thiol)-lyase. | Bifunctional enzyme CysN/CysC; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. | 0.597 |
SDO08965.1 | metE | SAMN04487957_103293 | SAMN04487957_10123 | O-acetylhomoserine (thiol)-lyase. | Methionine synthase (B12-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.974 |
SDO08965.1 | metN | SAMN04487957_103293 | SAMN04487957_11145 | O-acetylhomoserine (thiol)-lyase. | D-methionine transport system ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. | 0.537 |
SDO49007.1 | SDO07225.1 | SAMN04487957_10714 | SAMN04487957_103233 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.999 |
SDO49007.1 | SDO08965.1 | SAMN04487957_10714 | SAMN04487957_103293 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | O-acetylhomoserine (thiol)-lyase. | 0.531 |
SDO49007.1 | SDO75824.1 | SAMN04487957_10714 | SAMN04487957_11143 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | D-methionine transport system substrate-binding protein. | 0.441 |
SDO49007.1 | SDO75855.1 | SAMN04487957_10714 | SAMN04487957_11144 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | D-methionine transport system permease protein. | 0.599 |
SDO49007.1 | cysC | SAMN04487957_10714 | SAMN04487957_1097 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Bifunctional enzyme CysN/CysC; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. | 0.439 |
SDO49007.1 | metE | SAMN04487957_10714 | SAMN04487957_10123 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Methionine synthase (B12-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.976 |