STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
metE5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (748 aa)    
Predicted Functional Partners:
metK
S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
 0.931
OJG87192.1
5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.
 
 
 0.909
luxS
S-ribosylhomocysteine lyase 2; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family.
    
 0.876
OJG87854.1
Hypothetical protein.
  
 
 0.856
OJG90019.1
Hypothetical protein.
  
 
 0.851
metG
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily.
     
 0.843
OJG89873.1
Hypothetical protein; Belongs to the methylenetetrahydrofolate reductase family.
 
 
 0.787
OJG87190.1
Hypothetical protein; Belongs to the LysR transcriptional regulatory family.
 
  
 0.764
OJG87856.1
Hypothetical protein.
   
 
 0.676
OJG86775.1
Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family.
   
 
 0.676
Your Current Organism:
Enterococcus saccharolyticus
NCBI taxonomy Id: 41997
Other names: ATCC 43076, CCUG 27643, CCUG 33311, CIP 103246, DSM 20726, E. saccharolyticus, JCM 8734, LMG 11427, LMG:11427, NBRC 100493, NCDO 2594, NCIMB 702594, Streptococcus saccharolyticus
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.