node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Msm_0054 | aroA | Msm_0054 | Msm_0056 | 2'-5' RNA ligase, LigT; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. | Fructose-1,6-bisphosphate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. | 0.844 |
Msm_0054 | aroB | Msm_0054 | Msm_0055 | 2'-5' RNA ligase, LigT; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. | Predicted alternative 3-dehydroquinate synthase; Catalyzes the oxidative deamination and cyclization of 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis; Belongs to the archaeal-type DHQ synthase family. | 0.882 |
Msm_0054 | cca | Msm_0054 | Msm_0053 | 2'-5' RNA ligase, LigT; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. | tRNA nucleotidyltransferase (CCA-adding enzyme); Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. | 0.900 |
Msm_0141 | cca | Msm_0141 | Msm_0053 | dephospho-CoA kinase, CoaE; COG0237. | tRNA nucleotidyltransferase (CCA-adding enzyme); Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. | 0.554 |
Msm_0141 | dnaG | Msm_0141 | Msm_0427 | dephospho-CoA kinase, CoaE; COG0237. | DNA primase (type), DnaG; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | 0.598 |
Msm_0141 | spt5 | Msm_0141 | Msm_0624 | dephospho-CoA kinase, CoaE; COG0237. | Transcription antiterminator, NusG; Stimulates transcription elongation; Belongs to the archaeal Spt5 family. | 0.440 |
Msm_0217 | Msm_1375 | Msm_0217 | Msm_1375 | tRNA intron endonuclease, EndA; COG1676. | Predicted RNA-binding protein; COG1491. | 0.543 |
Msm_0217 | cca | Msm_0217 | Msm_0053 | tRNA intron endonuclease, EndA; COG1676. | tRNA nucleotidyltransferase (CCA-adding enzyme); Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. | 0.585 |
Msm_0217 | dnaG | Msm_0217 | Msm_0427 | tRNA intron endonuclease, EndA; COG1676. | DNA primase (type), DnaG; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | 0.916 |
Msm_0217 | nac | Msm_0217 | Msm_0384 | tRNA intron endonuclease, EndA; COG1676. | Transcription factor, NACalpha-BTF3 related; Contacts the emerging nascent chain on the ribosome. Belongs to the NAC-alpha family. | 0.501 |
Msm_0217 | spt5 | Msm_0217 | Msm_0624 | tRNA intron endonuclease, EndA; COG1676. | Transcription antiterminator, NusG; Stimulates transcription elongation; Belongs to the archaeal Spt5 family. | 0.600 |
Msm_0729 | cca | Msm_0729 | Msm_0053 | Molybdopterin biosynthesis protein, MoeB; COG0476. | tRNA nucleotidyltransferase (CCA-adding enzyme); Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. | 0.874 |
Msm_1375 | Msm_0217 | Msm_1375 | Msm_0217 | Predicted RNA-binding protein; COG1491. | tRNA intron endonuclease, EndA; COG1676. | 0.543 |
Msm_1375 | cca | Msm_1375 | Msm_0053 | Predicted RNA-binding protein; COG1491. | tRNA nucleotidyltransferase (CCA-adding enzyme); Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. | 0.638 |
Msm_1375 | dnaG | Msm_1375 | Msm_0427 | Predicted RNA-binding protein; COG1491. | DNA primase (type), DnaG; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | 0.753 |
Msm_1375 | nac | Msm_1375 | Msm_0384 | Predicted RNA-binding protein; COG1491. | Transcription factor, NACalpha-BTF3 related; Contacts the emerging nascent chain on the ribosome. Belongs to the NAC-alpha family. | 0.711 |
Msm_1375 | spt5 | Msm_1375 | Msm_0624 | Predicted RNA-binding protein; COG1491. | Transcription antiterminator, NusG; Stimulates transcription elongation; Belongs to the archaeal Spt5 family. | 0.714 |
aroA | Msm_0054 | Msm_0056 | Msm_0054 | Fructose-1,6-bisphosphate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. | 2'-5' RNA ligase, LigT; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. | 0.844 |
aroA | aroB | Msm_0056 | Msm_0055 | Fructose-1,6-bisphosphate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. | Predicted alternative 3-dehydroquinate synthase; Catalyzes the oxidative deamination and cyclization of 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis; Belongs to the archaeal-type DHQ synthase family. | 0.998 |
aroA | cca | Msm_0056 | Msm_0053 | Fructose-1,6-bisphosphate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. | tRNA nucleotidyltransferase (CCA-adding enzyme); Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. | 0.786 |