STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
psmAProteasome, alpha subunit, PsmA; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. (250 aa)    
Predicted Functional Partners:
pan
ATP-dependent 26S proteasome regulatory subunit, RPT1; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alo [...]
 
 0.971
psmB
Proteasome, beta subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
 
 
0.971
Msm_0462
Predicted metal-dependent protease, PAD1/JAB1 superfamily; COG1310.
   
 0.945
Msm_0244
Predicted exosome subunit; COG1500.
 
    0.915
Msm_0642
Cell division control protein Cdc48, AAA+ ATPase family; COG0464.
  
 0.883
rpl40e
Ribosomal protein L40e; COG1552; Belongs to the eukaryotic ribosomal protein eL40 family.
   
 0.836
Msm_0678
Conserved hypothetical membrane protein Msm_0678.
   
 0.836
rpl15e
Ribosomal protein L15e; COG1632; Belongs to the eukaryotic ribosomal protein eL15 family.
 
  
 0.831
rrp4
RNA-binding protein Rrp4; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.
 
  
 0.823
rrp42
Ribonuclease PH-related protein; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.
 
  
 0.786
Your Current Organism:
Methanobrevibacter smithii
NCBI taxonomy Id: 420247
Other names: M. smithii ATCC 35061, Methanobrevibacter smithii ATCC 35061, Methanobrevibacter smithii DSM 861, Methanobrevibacter smithii PS, Methanobrevibacter smithii str. ATCC 35061, Methanobrevibacter smithii strain ATCC 35061
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