STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Msm_0363Predicted RNA methylase; COG4076. (255 aa)    
Predicted Functional Partners:
Msm_0364
Transcriptional regulator (nickel-responsive), NikR; Transcriptional regulator; Belongs to the transcriptional regulatory CopG/NikR family.
       0.860
Msm_0361
Carbamoyl-phosphate synthase, large subunit, CarB; Catalyzes the synthesis of carbamoyl phosphate from ATP, ammonium and bicarbonate. Proceeds via a three-step mechanism, i.e. the phosphorylation of hydrogencarbonate to carboxyphosphate, a nucleophilic attack of ammonia on carboxyphosphate yielding carbamate, and the phosphorylation of carbamate forming carbamoyl phosphate. In M.smithii, the predominant archaeon in the human gut, one function of this enzyme may be to sequester ammonia, a scarce nutrient in the intestine which is the major source of nitrogen in M.smithii for the biosynt [...]
 
     0.818
Msm_0362
Coenzyme F420-reducing hydrogenase (Ni,Fe-hydrogenase maturation protease), delta subunit; COG0680.
       0.795
Msm_0360
Cell wall biosynthesis protein, phospho-N-acetylmuramoyl-pentapeptide-transferase family; COG0472.
 
     0.723
Msm_0767
Selenocysteine synthase, SelA; COG1921.
  
     0.559
Msm_0365
Conserved hypothetical protein Msm_0365.
       0.547
Msm_0359
Cell wall biosynthesis protein, MurD-like peptide ligase family; COG0769.
 
     0.508
Msm_0569
Phosphate transport system regulator-like protein, PhoU; COG0704.
  
     0.501
Msm_0190
Predicted ATPase; COG1365.
  
     0.474
Msm_0305
Conserved hypothetical membrane protein Msm_0305; COG3448.
  
     0.472
Your Current Organism:
Methanobrevibacter smithii
NCBI taxonomy Id: 420247
Other names: M. smithii ATCC 35061, Methanobrevibacter smithii ATCC 35061, Methanobrevibacter smithii DSM 861, Methanobrevibacter smithii PS, Methanobrevibacter smithii str. ATCC 35061, Methanobrevibacter smithii strain ATCC 35061
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