node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Msm_1151 | hisF | Msm_1151 | Msm_1364 | Adenylosuccinate lyase, PurB; COG0015; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Imidazoleglycerol-phosphate synthase, HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.828 |
Msm_1151 | hisH | Msm_1151 | Msm_1159 | Adenylosuccinate lyase, PurB; COG0015; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Glutamine amidotransferase, HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.835 |
Msm_1151 | hpt | Msm_1151 | Msm_1359 | Adenylosuccinate lyase, PurB; COG0015; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Adenine phosphoribosyltransferase, Apt; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | 0.981 |
Msm_1151 | purD | Msm_1151 | Msm_1227 | Adenylosuccinate lyase, PurB; COG0015; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylamine-glycine ligase, PurD; COG0151. | 0.998 |
Msm_1151 | purE | Msm_1151 | Msm_1287 | Adenylosuccinate lyase, PurB; COG0015; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylaminoimidazole carboxylase (NCAIR mutase), PurE; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.999 |
Msm_1151 | purL | Msm_1151 | Msm_1342 | Adenylosuccinate lyase, PurB; COG0015; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylformylglycinamidine (FGAM) synthase, PurL; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] | 0.998 |
Msm_1151 | purO | Msm_1151 | Msm_0976 | Adenylosuccinate lyase, PurB; COG0015; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | IMP cyclohydrolase, PurO; Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP. | 0.654 |
Msm_1151 | purP | Msm_1151 | Msm_0506 | Adenylosuccinate lyase, PurB; COG0015; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | ATP-utilizing enzyme, ATP-grasp superfamily; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. Belongs to the phosphohexose mutase family. | 0.946 |
Msm_1151 | purQ | Msm_1151 | Msm_1549 | Adenylosuccinate lyase, PurB; COG0015; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylformylglycinamidine (FGAM) synthase, PurQ; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] | 0.987 |
aroK | purO | Msm_0835 | Msm_0976 | Shikimate kinase; COG1685. | IMP cyclohydrolase, PurO; Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP. | 0.471 |
aroK | purP | Msm_0835 | Msm_0506 | Shikimate kinase; COG1685. | ATP-utilizing enzyme, ATP-grasp superfamily; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. Belongs to the phosphohexose mutase family. | 0.557 |
hisF | Msm_1151 | Msm_1364 | Msm_1151 | Imidazoleglycerol-phosphate synthase, HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | Adenylosuccinate lyase, PurB; COG0015; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.828 |
hisF | hisH | Msm_1364 | Msm_1159 | Imidazoleglycerol-phosphate synthase, HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | Glutamine amidotransferase, HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisF | hpt | Msm_1364 | Msm_1359 | Imidazoleglycerol-phosphate synthase, HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | Adenine phosphoribosyltransferase, Apt; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | 0.900 |
hisF | purD | Msm_1364 | Msm_1227 | Imidazoleglycerol-phosphate synthase, HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | Phosphoribosylamine-glycine ligase, PurD; COG0151. | 0.437 |
hisF | purP | Msm_1364 | Msm_0506 | Imidazoleglycerol-phosphate synthase, HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | ATP-utilizing enzyme, ATP-grasp superfamily; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. Belongs to the phosphohexose mutase family. | 0.805 |
hisH | Msm_1151 | Msm_1159 | Msm_1151 | Glutamine amidotransferase, HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | Adenylosuccinate lyase, PurB; COG0015; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.835 |
hisH | hisF | Msm_1159 | Msm_1364 | Glutamine amidotransferase, HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | Imidazoleglycerol-phosphate synthase, HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisH | hpt | Msm_1159 | Msm_1359 | Glutamine amidotransferase, HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | Adenine phosphoribosyltransferase, Apt; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | 0.818 |
hisH | purP | Msm_1159 | Msm_0506 | Glutamine amidotransferase, HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | ATP-utilizing enzyme, ATP-grasp superfamily; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. Belongs to the phosphohexose mutase family. | 0.805 |