STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
apgMPhosphoglycerate mutase, AP superfamily; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (412 aa)    
Predicted Functional Partners:
Msm_1435
Enolase; COG0148.
    
 0.923
pgk
3-phosphoglycerate kinase, Pgk; COG0126; Belongs to the phosphoglycerate kinase family.
    
 0.922
Msm_0153
Predicted phosphoglycerate mutase; COG3635.
  
  
 
0.911
Msm_0457
D-3-phosphoglycerate dehydrogenase, SerA; COG0111; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
    
 0.909
glmM
Phosphomannomutase, ManB; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family.
     
 0.888
fbp
Fructose 1,6-bisphosphatase; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
    
 0.838
aroA
Fructose-1,6-bisphosphate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
     
 0.833
Msm_0843
2-deoxyribose-5-phosphate aldolase (DERA), DeoC; COG0274.
     
  0.800
Msm_0659
Conserved hypothetical membrane protein Msm_0659; COG1836.
       0.734
Msm_0655
Glucose-1-phosphate thymidylyltransferase; COG1208.
 
     0.726
Your Current Organism:
Methanobrevibacter smithii
NCBI taxonomy Id: 420247
Other names: M. smithii ATCC 35061, Methanobrevibacter smithii ATCC 35061, Methanobrevibacter smithii DSM 861, Methanobrevibacter smithii PS, Methanobrevibacter smithii str. ATCC 35061, Methanobrevibacter smithii strain ATCC 35061
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