STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
argCAspartate-semialdehyde dehydrogenase, ArgC; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (339 aa)    
Predicted Functional Partners:
argH
Argininosuccinate lyase, ArgH; COG0165.
  
  
 0.999
argB
Acetylglutamate kinase, ArgB; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily.
 0.999
argJ
Glutamate N-acetyltransferase, ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family.
 
  
 0.999
argG
Argininosuccinate synthase, ArgG; COG0137; Belongs to the argininosuccinate synthase family. Type 1 subfamily.
 
  
 0.999
argD
N-acetylornithine aminotransferase, ArgD; COG4992; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
 
 
 0.998
argF
Ornithine carbamoyltransferase, ArgF; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
  
  
 0.933
hisA
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide (ProFAR) isomerase, HisA; COG0106.
  
  
 0.874
ribL
Glycerol-3-phosphate cytidylyltransferase; Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
       0.831
Msm_0861
Flavodoxin; COG0716.
       0.789
pyrI
Aspartate carbamoyltransferase regulatory chain, PyrI; Involved in allosteric regulation of aspartate carbamoyltransferase.
       0.749
Your Current Organism:
Methanobrevibacter smithii
NCBI taxonomy Id: 420247
Other names: M. smithii ATCC 35061, Methanobrevibacter smithii ATCC 35061, Methanobrevibacter smithii DSM 861, Methanobrevibacter smithii PS, Methanobrevibacter smithii str. ATCC 35061, Methanobrevibacter smithii strain ATCC 35061
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