BK809_0001126 protein (Diplodia seriata) - STRING interaction network

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Score

BK809_0001126

Glutathione S-transferase 1. (183 aa)

Predicted Functional Partners:

BK809_0004824

0.909

BK809_0005822

0.909

BK809_0004370

0.864

BK809_0003170

0.848

BK809_0007154

0.774

BK809_0002797

0.759

BK809_0001021

0.755

BK809_0003194

0.748

BK809_0003424

0.747

BK809_0002568

0.740

Your Current Organism:

Diplodia seriata

NCBI taxonomy Id: 420778
Other names: Botryosphaeria obtusa, CBS 112555, D. seriata

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BK809_0001021	BK809_0001126	A0A1S8B6K2	A0A1S8B610	Microsomal glutathione S-transferase 3.	Glutathione S-transferase 1.	0.755
BK809_0001021	BK809_0002568	A0A1S8B6K2	A0A0G2EWT2	Microsomal glutathione S-transferase 3.	Mitochondrial peroxiredoxin PRX1.	0.695
BK809_0001021	BK809_0002797	A0A1S8B6K2	A0A0G2GCH9	Microsomal glutathione S-transferase 3.	Putative glutathione s-transferase; Belongs to the GST superfamily.	0.755
BK809_0001021	BK809_0003194	A0A1S8B6K2	A0A1S8BLR9	Microsomal glutathione S-transferase 3.	Glutathione S-transferase omega-1; Belongs to the GST superfamily.	0.755
BK809_0001021	BK809_0003424	A0A1S8B6K2	A0A1S8BFG1	Microsomal glutathione S-transferase 3.	Glutathione S-transferase omega-1; Belongs to the GST superfamily.	0.755
BK809_0001021	BK809_0004370	A0A1S8B6K2	A0A1S8BDZ5	Microsomal glutathione S-transferase 3.	Glutathione S-transferase 3.	0.762
BK809_0001021	BK809_0004824	A0A1S8B6K2	A0A1S8B7R7	Microsomal glutathione S-transferase 3.	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	0.903
BK809_0001021	BK809_0007154	A0A1S8B6K2	A0A1S8BIC5	Microsomal glutathione S-transferase 3.	Glutathione S-transferase A4.	0.768
BK809_0001126	BK809_0001021	A0A1S8B610	A0A1S8B6K2	Glutathione S-transferase 1.	Microsomal glutathione S-transferase 3.	0.755
BK809_0001126	BK809_0002568	A0A1S8B610	A0A0G2EWT2	Glutathione S-transferase 1.	Mitochondrial peroxiredoxin PRX1.	0.740
BK809_0001126	BK809_0002797	A0A1S8B610	A0A0G2GCH9	Glutathione S-transferase 1.	Putative glutathione s-transferase; Belongs to the GST superfamily.	0.759
BK809_0001126	BK809_0003170	A0A1S8B610	A0A0G2G3X2	Glutathione S-transferase 1.	Putative elongation factor 1-beta.	0.848
BK809_0001126	BK809_0003194	A0A1S8B610	A0A1S8BLR9	Glutathione S-transferase 1.	Glutathione S-transferase omega-1; Belongs to the GST superfamily.	0.748
BK809_0001126	BK809_0003424	A0A1S8B610	A0A1S8BFG1	Glutathione S-transferase 1.	Glutathione S-transferase omega-1; Belongs to the GST superfamily.	0.747
BK809_0001126	BK809_0004370	A0A1S8B610	A0A1S8BDZ5	Glutathione S-transferase 1.	Glutathione S-transferase 3.	0.864
BK809_0001126	BK809_0004824	A0A1S8B610	A0A1S8B7R7	Glutathione S-transferase 1.	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	0.909
BK809_0001126	BK809_0005822	A0A1S8B610	A0A1S8BNL2	Glutathione S-transferase 1.	Glutathione synthetase.	0.909
BK809_0001126	BK809_0007154	A0A1S8B610	A0A1S8BIC5	Glutathione S-transferase 1.	Glutathione S-transferase A4.	0.774
BK809_0002568	BK809_0001021	A0A0G2EWT2	A0A1S8B6K2	Mitochondrial peroxiredoxin PRX1.	Microsomal glutathione S-transferase 3.	0.695
BK809_0002568	BK809_0001126	A0A0G2EWT2	A0A1S8B610	Mitochondrial peroxiredoxin PRX1.	Glutathione S-transferase 1.	0.740

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Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.925

expected number of edges:

12

PPI enrichment p-value:

3.47e-14

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009073

Aromatic amino acid family biosynthetic process

9 of 10

2.5

8.01

1.26e-17

GO:0046417

Chorismate metabolic process

8 of 8

2.54

7.39

7.49e-16

GO:0009423

Chorismate biosynthetic process

7 of 7

2.54

6.39

1.43e-13

GO:0016053

Organic acid biosynthetic process

10 of 158

1.34

2.28

3.71e-11

GO:0008652

Cellular amino acid biosynthetic process

8 of 112

1.4

2.16

1.24e-08

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004764

Shikimate 3-dehydrogenase (NADP+) activity

2 of 2

2.54

0.83

0.0304

GO:0016838

Carbon-oxygen lyase activity, acting on phosphates

2 of 4

2.24

0.78

0.0371

GO:0016835

Carbon-oxygen lyase activity

3 of 32

1.51

0.7

0.0371

GO:0016829

Lyase activity

4 of 95

1.17

0.6

0.0371

GO:0003824

Catalytic activity

11 of 1844

0.32

0.24

0.0451

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:25072253

(2014) Identification of polyketide inhibitors targeting 3-dehydroquinate dehydratase in the shikimate pathway of Enterococcus faecalis.

3 of 3

2.54

1.55

0.0014

PMID:24586713

(2014) Discovery of selective inhibitors of the Clostridium difficile dehydroquinate dehydratase.

3 of 3

2.54

1.55

0.0014

PMID:35163582

(2022) Comparison of Automated Ribotyping, spa Typing, and MLST in 108 Clinical Isolates of Staphylococcus aureus from Orthopedic Infections.

3 of 4

2.42

1.54

0.0014

PMID:32391366

(2020) Prevalence, Characterization, and Drug Resistance of Staphylococcus Aureus in Feces From Pediatric Patients in Guangzhou, China.

3 of 5

2.32

1.52

0.0014

PMID:36873553

(2023) The effect of different C. difficile MLST strains on viability and activity of macrophages.

3 of 6

2.24

1.51

0.0014

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1319

Aromatic amino acid family biosynthetic process, and CorA, cytoplasmic domain

9 of 12

2.42

7.64

2.90e-17

CL:1322

Chorismate metabolic process

6 of 6

2.54

5.46

1.70e-11

CL:1291

Mixed, incl. Histidine biosynthetic process, and Aromatic amino acid family biosynthetic process

10 of 43

1.91

5.27

5.00e-16

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pdc00400

Phenylalanine, tyrosine and tryptophan biosynthesis

10 of 17

2.31

8.23

4.91e-20

pdc01230

Biosynthesis of amino acids

9 of 116

1.43

2.53

8.08e-11

pdc01110

Biosynthesis of secondary metabolites

10 of 235

1.17

1.71

3.28e-10

pdc01100

Metabolic pathways

11 of 605

0.8

0.85

4.23e-08

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0057

Aromatic amino acid biosynthesis

7 of 7

2.54

6.47

9.59e-14

KW-0521

NADP

3 of 23

1.66

1.19

0.0030

KW-0456

Lyase

4 of 92

1.18

0.85

0.0055

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF08501

Shikimate dehydrogenase substrate binding domain

2 of 2

2.54

0.86

0.0274

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