node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
LCGL_0002 | LCGL_0085 | LCGL_0002 | LCGL_0085 | DNA polymerase III beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Deoxyuridine 5'-triphosphate nucleotidhydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.775 |
LCGL_0002 | LCGL_1322 | LCGL_0002 | LCGL_1322 | DNA polymerase III beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Ribonucleotide reductase alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.757 |
LCGL_0002 | thyA | LCGL_0002 | LCGL_1207 | DNA polymerase III beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.745 |
LCGL_0083 | LCGL_0084 | LCGL_0083 | LCGL_0084 | Conserved hypothetical protein; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Conserved hypothetical protein. | 0.881 |
LCGL_0083 | LCGL_0085 | LCGL_0083 | LCGL_0085 | Conserved hypothetical protein; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Deoxyuridine 5'-triphosphate nucleotidhydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.698 |
LCGL_0084 | LCGL_0083 | LCGL_0084 | LCGL_0083 | Conserved hypothetical protein. | Conserved hypothetical protein; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 0.881 |
LCGL_0084 | LCGL_0085 | LCGL_0084 | LCGL_0085 | Conserved hypothetical protein. | Deoxyuridine 5'-triphosphate nucleotidhydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.688 |
LCGL_0085 | LCGL_0002 | LCGL_0085 | LCGL_0002 | Deoxyuridine 5'-triphosphate nucleotidhydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | DNA polymerase III beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.775 |
LCGL_0085 | LCGL_0083 | LCGL_0085 | LCGL_0083 | Deoxyuridine 5'-triphosphate nucleotidhydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Conserved hypothetical protein; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 0.698 |
LCGL_0085 | LCGL_0084 | LCGL_0085 | LCGL_0084 | Deoxyuridine 5'-triphosphate nucleotidhydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Conserved hypothetical protein. | 0.688 |
LCGL_0085 | LCGL_0902 | LCGL_0085 | LCGL_0902 | Deoxyuridine 5'-triphosphate nucleotidhydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | dCMP deaminase. | 0.942 |
LCGL_0085 | LCGL_0941 | LCGL_0085 | LCGL_0941 | Deoxyuridine 5'-triphosphate nucleotidhydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Nucleoside diphosphate kinase. | 0.935 |
LCGL_0085 | LCGL_1322 | LCGL_0085 | LCGL_1322 | Deoxyuridine 5'-triphosphate nucleotidhydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Ribonucleotide reductase alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.739 |
LCGL_0085 | LCGL_1827 | LCGL_0085 | LCGL_1827 | Deoxyuridine 5'-triphosphate nucleotidhydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Anaerobic ribonucleoside-triphosphate reductase. | 0.926 |
LCGL_0085 | tdk | LCGL_0085 | LCGL_1555 | Deoxyuridine 5'-triphosphate nucleotidhydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Thymidine kinase. | 0.960 |
LCGL_0085 | thyA | LCGL_0085 | LCGL_1207 | Deoxyuridine 5'-triphosphate nucleotidhydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.963 |
LCGL_0085 | tmk | LCGL_0085 | LCGL_0272 | Deoxyuridine 5'-triphosphate nucleotidhydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.945 |
LCGL_0902 | LCGL_0085 | LCGL_0902 | LCGL_0085 | dCMP deaminase. | Deoxyuridine 5'-triphosphate nucleotidhydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.942 |
LCGL_0902 | tdk | LCGL_0902 | LCGL_1555 | dCMP deaminase. | Thymidine kinase. | 0.932 |
LCGL_0902 | thyA | LCGL_0902 | LCGL_1207 | dCMP deaminase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.941 |