node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
LCGL_0352 | LCGL_1611 | LCGL_0352 | LCGL_1611 | Transcription regulator; Belongs to the CtsR family. | ATP-dependent Clp protease ATP-binding subunit; Belongs to the ClpA/ClpB family. | 0.849 |
LCGL_0352 | clpB | LCGL_0352 | LCGL_0940 | Transcription regulator; Belongs to the CtsR family. | Chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.499 |
LCGL_0352 | clpP | LCGL_0352 | LCGL_0361 | Transcription regulator; Belongs to the CtsR family. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.797 |
LCGL_0352 | dnaK | LCGL_0352 | LCGL_0422 | Transcription regulator; Belongs to the CtsR family. | Heat shock protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.437 |
LCGL_0352 | groL | LCGL_0352 | LCGL_0268 | Transcription regulator; Belongs to the CtsR family. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.430 |
LCGL_0352 | groS | LCGL_0352 | LCGL_0267 | Transcription regulator; Belongs to the CtsR family. | Chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.453 |
LCGL_0352 | grpE | LCGL_0352 | LCGL_0421 | Transcription regulator; Belongs to the CtsR family. | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.422 |
LCGL_0352 | hrcA | LCGL_0352 | LCGL_0420 | Transcription regulator; Belongs to the CtsR family. | Transcription regulator; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.791 |
LCGL_0418 | grpE | LCGL_0418 | LCGL_0421 | D-alanyl-D-alanine carboxypeptidase. | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.429 |
LCGL_0418 | hrcA | LCGL_0418 | LCGL_0420 | D-alanyl-D-alanine carboxypeptidase. | Transcription regulator; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.490 |
LCGL_1611 | LCGL_0352 | LCGL_1611 | LCGL_0352 | ATP-dependent Clp protease ATP-binding subunit; Belongs to the ClpA/ClpB family. | Transcription regulator; Belongs to the CtsR family. | 0.849 |
LCGL_1611 | clpP | LCGL_1611 | LCGL_0361 | ATP-dependent Clp protease ATP-binding subunit; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.951 |
LCGL_1611 | dnaJ | LCGL_1611 | LCGL_1928 | ATP-dependent Clp protease ATP-binding subunit; Belongs to the ClpA/ClpB family. | Heat shock protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | 0.750 |
LCGL_1611 | dnaK | LCGL_1611 | LCGL_0422 | ATP-dependent Clp protease ATP-binding subunit; Belongs to the ClpA/ClpB family. | Heat shock protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.945 |
LCGL_1611 | groL | LCGL_1611 | LCGL_0268 | ATP-dependent Clp protease ATP-binding subunit; Belongs to the ClpA/ClpB family. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.858 |
LCGL_1611 | groS | LCGL_1611 | LCGL_0267 | ATP-dependent Clp protease ATP-binding subunit; Belongs to the ClpA/ClpB family. | Chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.662 |
LCGL_1611 | grpE | LCGL_1611 | LCGL_0421 | ATP-dependent Clp protease ATP-binding subunit; Belongs to the ClpA/ClpB family. | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.778 |
LCGL_1611 | hrcA | LCGL_1611 | LCGL_0420 | ATP-dependent Clp protease ATP-binding subunit; Belongs to the ClpA/ClpB family. | Transcription regulator; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.634 |
clpB | LCGL_0352 | LCGL_0940 | LCGL_0352 | Chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Transcription regulator; Belongs to the CtsR family. | 0.499 |
clpB | clpP | LCGL_0940 | LCGL_0361 | Chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.893 |