Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (270 aa)    
Predicted Functional Partners:
LCGL_1780
Tetracycline-efflux transporter protein.
 
      0.788
pepT
Tripeptidase; Cleaves the N-terminal amino acid of tripeptides. Belongs to the peptidase M20B family.
     
 0.735
LCGL_1300
Coproporphyrogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family.
  
  
 0.702
dnaK
Heat shock protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
    
 0.600
clpP
ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
   
 0.589
mntH
Manganese transporter protein; H(+)-stimulated, divalent metal cation uptake system. Belongs to the NRAMP family.
  
  
 0.501
hrcA
Transcription regulator; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.
     
 0.483
atpD
F0F1-type ATP synthase beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family.
   
 0.451
LCGL_0352
Transcription regulator; Belongs to the CtsR family.
      
 0.436
LCGL_1883
Alcohol-acetaldehyde dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
   
 
 0.410
Your Current Organism:
Lactococcus garvieae
NCBI taxonomy Id: 420890
Other names: L. garvieae Lg2, Lactococcus garvieae Lg2, Lactococcus garvieae str. Lg2, Lactococcus garvieae strain Lg2
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